Journal article
Acne and hidradenitis suppurativa.
- Pink A St John's Institute of Dermatology, Division of Genetics and Molecular Medicine, Guy's Hospital, King's College, London, SE1 9RT, U.K.
- Anzengruber F Department of Dermatology, University Hospital Zurich, Zurich, 8091, Switzerland.
- Navarini AA Department of Dermatology, University Hospital Zurich, Zurich, 8091, Switzerland.
- 2018-01-31
Published in:
- The British journal of dermatology. - 2018
Acne Vulgaris
Adolescent
Adult
Bacterial Infections
Child
Cytokines
Female
Hair Diseases
Hair Follicle
Hidradenitis Suppurativa
Hormones
Humans
Immunity, Cellular
Male
Mutation, Missense
Obesity
Phenotype
Sebaceous Gland Diseases
Smoking
Young Adult
English
Acne and hidradenitis suppurativa (HS) both centre on hair follicles. They often occur together as part of the acne tetrad, but are found in distinct localizations. Acne is primarily defined by the presence of comedones and inflammatory lesions. However, in HS the intertriginous localization and chronicity play equally important roles for the diagnosis to the inflammatory lesions. Genetics, bacteria, environmental factors and innate inflammation have all been found to play a role in acne and/or HS. Surprisingly, there is little overlap between the findings so far. The genetics of acne and HS are distinct, bacteria have not been shown convincingly to play a role in HS, and the important risk factors obesity and smoking in HS cannot be easily translated to acne. The one driving factor central to both diseases is innate inflammation, most strikingly involving interleukin-1. Hence the interleukin-1 family, as already shown in autoinflammatory conditions associated with acne, could represent attractive treatment targets.
- Language
-
- English
- Open access status
- closed
- Identifiers
-
- DOI 10.1111/bjd.16231
- PMID 29380349
- Persistent URL
- https://sonar.ch/global/documents/67322
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