The Multifaceted Pyruvate Metabolism: Role of the Mitochondrial Pyruvate Carrier.
- Zangari J Department of Cell Biology, Faculty of Sciences, University of Geneva, 30 Quai Ernest Ansermet, 1211 Geneva 4, Switzerland.
- Petrelli F Department of Cell Biology, Faculty of Sciences, University of Geneva, 30 Quai Ernest Ansermet, 1211 Geneva 4, Switzerland.
- Maillot B Department of Cell Biology, Faculty of Sciences, University of Geneva, 30 Quai Ernest Ansermet, 1211 Geneva 4, Switzerland.
- Martinou JC Department of Cell Biology, Faculty of Sciences, University of Geneva, 30 Quai Ernest Ansermet, 1211 Geneva 4, Switzerland.
- 2020-07-26
Published in:
- Biomolecules. - 2020
English
Pyruvate, the end product of glycolysis, plays a major role in cell metabolism. Produced in the cytosol, it is oxidized in the mitochondria where it fuels the citric acid cycle and boosts oxidative phosphorylation. Its sole entry point into mitochondria is through the recently identified mitochondrial pyruvate carrier (MPC). In this review, we report the latest findings on the physiology of the MPC and we discuss how a dysfunctional MPC can lead to diverse pathologies, including neurodegenerative diseases, metabolic disorders, and cancer.
- Language
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- English
- Open access status
- gold
- Identifiers
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- DOI 10.3390/biom10071068
- PMID 32708919
- Persistent URL
- https://sonar.ch/global/documents/70427
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