Journal article
Enhanced quantitative susceptibility mapping (QSM) using real-time field control.
- Özbay PS University Hospital Zurich and University of Zurich, Institute of Diagnostic and Interventional Radiology, Zurich, Switzerland.
- Duerst Y ETH Zurich and University of Zurich, Institute for Biomedical Engineering, Zurich, Switzerland.
- Wilm BJ ETH Zurich and University of Zurich, Institute for Biomedical Engineering, Zurich, Switzerland.
- Pruessmann KP ETH Zurich and University of Zurich, Institute for Biomedical Engineering, Zurich, Switzerland.
- Nanz D University Hospital Zurich and University of Zurich, Institute of Diagnostic and Interventional Radiology, Zurich, Switzerland.
- 2017-05-31
Published in:
- Magnetic resonance in medicine. - 2018
7 T
NMR field probes
field control
gradient echo
phase
quantitative susceptibility mapping (QSM)
Algorithms
Brain
Humans
Image Processing, Computer-Assisted
Magnetic Resonance Imaging
Phantoms, Imaging
English
PURPOSE
To assess the potential of a real-time field-control (FC) system for mitigating effects of spatiotemporal field fluctuations in quantitative susceptibility mapping (QSM) at 7 T.
METHODS
Magnitude, phase, and QSM images of phantoms and healthy volunteers were acquired under standard conditions and under induced field perturbation (FP) (phantoms: periodic water-bottle displacement; volunteers: deep breathing and forearm movement) with and without FC, which continuously detects and minimizes magnetic-field variations.
RESULTS
Field control successfully eliminated FP-induced impairment of phantom image quality and deviations from a linear susceptibility increase for increasing gadolinium concentration in a Gd dilution series (y = 320x - 0.60, R2 = 0.93 for the scan with FP and FC versus y = 259x - 0.54, R2 = 0.78 for the scan with FP and no FC (slope literature value: 326 ppm L/mol)). Similarly, in volunteers, FC allowed a recovery of a FP-induced loss of identifiable brain structures and reduced the relative change of mean susceptibilities and standard deviations (93 ± 53% to 34 ± 46%) in all regions of interests with respect to the reference scan.
CONCLUSIONS
Real-time FC improved the delineation of brain structures and the match of susceptibility values with reference values obtained without FP. Magn Reson Med 79:770-778, 2018. © 2017 International Society for Magnetic Resonance in Medicine.
To assess the potential of a real-time field-control (FC) system for mitigating effects of spatiotemporal field fluctuations in quantitative susceptibility mapping (QSM) at 7 T.
METHODS
Magnitude, phase, and QSM images of phantoms and healthy volunteers were acquired under standard conditions and under induced field perturbation (FP) (phantoms: periodic water-bottle displacement; volunteers: deep breathing and forearm movement) with and without FC, which continuously detects and minimizes magnetic-field variations.
RESULTS
Field control successfully eliminated FP-induced impairment of phantom image quality and deviations from a linear susceptibility increase for increasing gadolinium concentration in a Gd dilution series (y = 320x - 0.60, R2 = 0.93 for the scan with FP and FC versus y = 259x - 0.54, R2 = 0.78 for the scan with FP and no FC (slope literature value: 326 ppm L/mol)). Similarly, in volunteers, FC allowed a recovery of a FP-induced loss of identifiable brain structures and reduced the relative change of mean susceptibilities and standard deviations (93 ± 53% to 34 ± 46%) in all regions of interests with respect to the reference scan.
CONCLUSIONS
Real-time FC improved the delineation of brain structures and the match of susceptibility values with reference values obtained without FP. Magn Reson Med 79:770-778, 2018. © 2017 International Society for Magnetic Resonance in Medicine.
- Language
-
- English
- Open access status
- closed
- Identifiers
-
- DOI 10.1002/mrm.26735
- PMID 28556247
- Persistent URL
- https://sonar.ch/global/documents/71860
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