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Melatonin rhythms in renal transplant recipients with sleep-wake disturbances.
Journal article

Melatonin rhythms in renal transplant recipients with sleep-wake disturbances.

  • Burkhalter H a Centre for Sleep Medicine , Hirslanden Group , Zürich , Switzerland.
  • De Geest S b Institute of Nursing Science, University of Basel , Basel , Switzerland.
  • Wirz-Justice A d Centre for Chronobiology , Psychiatric Hospital of the University of Basel , Basel , Switzerland.
  • Cajochen C d Centre for Chronobiology , Psychiatric Hospital of the University of Basel , Basel , Switzerland.
  • 2016-04-22
Published in:
  • Chronobiology international. - 2016
Adults
chronobiology
kidney transplantation
melatonin profile
rental transplant recipients
salivary melatonin
sleep-wake disturbances
Adult
Aged
Circadian Rhythm
Female
Humans
Kidney Transplantation
Light
Male
Melatonin
Middle Aged
Saliva
Sleep
Sleep Wake Disorders
Surveys and Questionnaires
English We assessed salivary melatonin levels in renal transplant (RTx) recipients who participated in a randomised, multicentre wait-list controlled trial on the effect of bright light therapy on their sleep and circadian rhythms. A large proportion of RTx recipients in our cohort had unexpectedly low melatonin values, which precluded calculation of the dim-light melatonin onset (DLMO) as a circadian marker. Thus, the aim of this post hoc analysis was to describe the melatonin profile of home-dwelling RTx recipients diagnosed with sleep-wake disturbances (SWDs). The participants were characterised by means of sleep questionnaires, validated psychometric instruments [Pittsburgh sleep quality Index (PSQI), Epworth sleepiness scale (ESS), Morningness-Eveningness Questionnaire (MEQ) and Depression, Anxiety and Stress Scale (DASS)] in addition to melatonin assay in saliva. Data were analysed with descriptive statistics and group comparisons made with appropriate post hoc tests. RTx recipients [n = 29 (aged 54.83 ± 13.73, transplanted 10.62 ± 6.84 years ago)] were retrospectively grouped into two groups: RTx recipients whose dim light melatonin onset (DLMO) could be calculated (n = 11) and those whose DLMO could not be calculated (n = 18). RTx recipients having a measurable DLMO had a number of differences from those without DLMO: they were younger [46.4 ± 14.9 compared to 60.0 ± 10.3 (p = .007)], had higher haemoglobin values [135.36 ± 12.01 versus 122.82 ± 11.56 (p = .01)], less anxiety [4 (0;8) versus 12 (6.5;14) (p = .021)] and a better overall sense of coherence [SOC Score: 71.09 ± 12.78 versus 56.28 ± 15.48 (p = 0.013)]. These results suggest that RTx recipients whose DLMO could be calculated have less health impairments, underlying the relevance of a stable circadian system.
Language
  • English
Open access status
closed
Identifiers
Persistent URL
https://sonar.ch/global/documents/73575
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