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Severe spontaneous vertebral fractures after denosumab discontinuation: three case reports.
Journal article

Severe spontaneous vertebral fractures after denosumab discontinuation: three case reports.

  • Aubry-Rozier B Center of Bone Diseases, Bone and Joint Department, Lausanne University Hospital, Av. Pierre-Decker 4, 1011, Lausanne, Switzerland. berengere.aubry@chuv.ch.
  • Gonzalez-Rodriguez E Center of Bone Diseases, Bone and Joint Department, Lausanne University Hospital, Av. Pierre-Decker 4, 1011, Lausanne, Switzerland.
  • Stoll D Center of Bone Diseases, Bone and Joint Department, Lausanne University Hospital, Av. Pierre-Decker 4, 1011, Lausanne, Switzerland.
  • Lamy O Center of Bone Diseases, Bone and Joint Department, Lausanne University Hospital, Av. Pierre-Decker 4, 1011, Lausanne, Switzerland.
  • 2015-10-30
Published in:
  • Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA. - 2016
Denosumab discontinuation
Osteoporotic fracture
Osteoporotic treatment duration
Aged
Bone Density Conservation Agents
Denosumab
Drug Administration Schedule
Female
Fractures, Spontaneous
Humans
Middle Aged
Osteoporosis, Postmenopausal
Osteoporotic Fractures
Spinal Fractures
Withholding Treatment
English Osteoporosis treatments are usually given for a limited period of time in order to balance benefits and risks. We report three cases of postmenopausal women without any previous fragility fracture who presented severe spontaneous vertebral fractures after denosumab discontinuation. We think that the occurrence of these fractures could be explained by the severe rebound effect observed after denosumab discontinuation and that a consensus regarding the end of treatment with denosumab has to be defined.
Language
  • English
Open access status
closed
Identifiers
Persistent URL
https://sonar.ch/global/documents/78623
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