Journal article
Gammadelta T cells: an alternative type of professional APC.
- 2006-01-31
Published in:
- Trends in immunology. - 2006
Antigen Presentation
Antigen-Presenting Cells
Chemokines
Humans
Lymphocyte Activation
Models, Immunological
Receptors, Antigen, T-Cell, gamma-delta
T-Lymphocytes
English
A subtype of activated human gammadelta T cells, termed Vdelta2+ T cells, has antigen-presentation features similar in potency and efficacy to those seen in dendritic cells. Comparable treatment of alphabeta T cells does not result in 'professional' antigen presenting cells (APCs). What is so special about Vdelta2+ T cells? How do they acquire these unexpected properties? Under what physiological conditions would such a bridge between innate and adaptive immunity come into play? In addition to discussing these questions, we introduce a model that correlates the expression of lymph node homing receptors in Vdelta2+ T cells with the involvement of this alternative type of APC in anti-microbial alphabeta T cell responses.
- Language
-
- English
- Open access status
- closed
- Identifiers
-
- DOI 10.1016/j.it.2006.01.002
- PMID 16442347
- Persistent URL
- https://sonar.ch/global/documents/79504
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