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First experience of SARS-CoV-2 infections in solid organ transplant recipients in the Swiss Transplant Cohort Study.

  • Tschopp J Infectious Diseases Service, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland.
  • L'Huillier AG Pediatric Infectious Diseases Unit, University Hospitals of Geneva and Faculty of Medicine, Genève, Switzerland.
  • Mombelli M Infectious Diseases Service, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland.
  • Mueller NJ Division of Infectious Diseases and Hospital Epidemiology, University Hospital Zurich, Zürich, Switzerland.
  • Khanna N Infectious Diseases & Hospital Epidemiology, University Hospital Basel, Basel, Switzerland.
  • Garzoni C Clinic of Internal Medicine and Infectious Diseases, Clinica Luganese Moncucco, Lugano, Switzerland.
  • Meloni D Clinic of Internal Medicine and Infectious Diseases, Clinica Luganese Moncucco, Lugano, Switzerland.
  • Papadimitriou-Olivgeris M Infectious Diseases Service, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland.
  • Neofytos D Transplant Infectious Diseases Unit, University Hospitals of Geneva and Faculty of Medicine, Genève, Switzerland.
  • Hirsch HH Infectious Diseases & Hospital Epidemiology, University Hospital Basel, Basel, Switzerland.
  • Schuurmans MM Pulmonology, University Hospital Zurich, Zürich, Switzerland.
  • Müller T Nephrology clinic, University Hospital Zurich, Zürich, Switzerland.
  • Berney T Service of Transplantation, University Hospitals of Geneva and Faculty of Medicine, Genève, Switzerland.
  • Steiger J Department for Transplantation Immunology and Nephrology, Basel, Switzerland.
  • Pascual M Transplantation Center, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland.
  • Manuel O Infectious Diseases Service, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland.
  • van Delden C Transplant Infectious Diseases Unit, University Hospitals of Geneva and Faculty of Medicine, Genève, Switzerland.
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  • 2020-05-16
Published in:
  • American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons. - 2020
clinical research/ practice
complication: infectious
infection and infectious agents
infection and infectious agents - viral
infectious disease
Aged
Betacoronavirus
Comorbidity
Coronavirus Infections
Disease Transmission, Infectious
Female
Follow-Up Studies
Humans
Incidence
Male
Middle Aged
Organ Transplantation
Pandemics
Pneumonia, Viral
Postoperative Complications
Prospective Studies
Survival Rate
Switzerland
Transplant Recipients
English Immunocompromised patients may be at increased risk for complications of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection. However, comprehensive data of SARS-CoV-2 infection in solid organ transplant (SOT) recipients are still lacking. We performed a multicenter nationwide observational study within the Swiss Transplant Cohort Study (STCS) to describe the epidemiology, clinical presentation, treatment and outcomes of the first microbiologically documented SARS-CoV-2 infection among SOT recipients. Overall, 21 patients were included with a median age of 56 years (10 kidney, 5 liver, 1 pancreas, 1 lung, 1 heart and 3 combined transplantations). The most common presenting symptoms were fever (76%), dry cough (57%), nausea (33%), and diarrhea (33%). Ninety-five percent and 24% of patients required hospital and ICU admission, respectively, and 19% were intubated. After a median of 33 days of follow-up, 16 patients were discharged, 3 were still hospitalized and 2 patients died. These data suggest that clinical manifestations of SARS-CoV-2 infection in middle-aged SOT recipients appear to be similar to the general population without an apparent higher rate of complications. These results need to be confirmed in larger cohorts.
Language
  • English
Open access status
bronze
Identifiers
Persistent URL
https://sonar.ch/global/documents/82309
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