Journal article
TSC on the peroxisome controls mTORC1.
- Benjamin D Biozentrum, University of Basel, CH4056 Basel, Switzerland.
- Hall MN
- 2013-10-03
Published in:
- Nature cell biology. - 2013
Animals
Humans
Lysosomes
Models, Biological
Peroxisomes
Protein Binding
TOR Serine-Threonine Kinases
Tuberous Sclerosis
English
mTOR is a central controller that integrates many inputs to regulate cell growth and ensure cellular homeostasis. The mTORC1 inhibitor TSC (tuberous sclerosis complex) on the peroxisome is found to inhibit mTORC1 in response to endogenous reactive oxygen species. Thus, mTOR may avoid confounding different inputs by sensing them at different cellular locations.
- Language
-
- English
- Open access status
- closed
- Identifiers
-
- DOI 10.1038/ncb2849
- PMID 24084861
- Persistent URL
- https://sonar.ch/global/documents/83840
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