A three-generation study on the association of tobacco smoking with asthma.
- Accordini S Unit of Epidemiology and Medical Statistics, Department of Diagnostics and Public Health, University of Verona, Verona, Italy.
- Calciano L Unit of Epidemiology and Medical Statistics, Department of Diagnostics and Public Health, University of Verona, Verona, Italy.
- Johannessen A Centre for International Health, Department of Global Public Health and Primary Care, University of Bergen, Bergen, Norway.
- Portas L Unit of Epidemiology and Medical Statistics, Department of Diagnostics and Public Health, University of Verona, Verona, Italy.
- Benediktsdóttir B Faculty of Medicine, University of Iceland, Reykjavik, Iceland.
- Bertelsen RJ Department of Clinical Science, University of Bergen, Bergen, Norway.
- Bråbäck L Division of Occupational and Environmental Medicine, Department of Public Health and Clinical Medicine, Umeå University, Umeå, Sweden.
- Carsin AE ISGlobal, Centre for Research in Environmental Epidemiology (CREAL), Barcelona, Spain.
- Dharmage SC School of Population and Global Health, University of Melbourne, Melbourne, VIC, Australia.
- Dratva J ZHAW School of Health Professions, Institute of Health Sciences, Winterthur, Switzerland.
- Forsberg B Division of Occupational and Environmental Medicine, Department of Public Health and Clinical Medicine, Umeå University, Umeå, Sweden.
- Gomez Real F Department of Clinical Science, University of Bergen, Bergen, Norway.
- Heinrich J Institute and Outpatient Clinic for Occupational, Social and Environmental Medicine, Inner City Clinic, University Hospital Munich, Ludwig-Maximilians-Universität München, Munich, Germany.
- Holloway JW Human Development and Health, Faculty of Medicine, University of Southampton, Southampton, UK.
- Holm M Department of Occupational and Environmental Medicine, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden.
- Janson C Department of Medical Sciences: Respiratory, Allergy and Sleep Research, Uppsala University, Uppsala, Sweden.
- Jögi R Lung Clinic, Tartu University Hospital, Tartu, Estonia.
- Leynaert B INSERM UMR 1152, Pathophysiology and Epidemiology of Respiratory Diseases, Paris, France.
- Malinovschi A Department of Medical Sciences: Clinical Physiology, Uppsala University, Uppsala, Sweden.
- Marcon A Unit of Epidemiology and Medical Statistics, Department of Diagnostics and Public Health, University of Verona, Verona, Italy.
- Martínez-Moratalla Rovira J Pneumology Service of the University Hospital Complex of Albacete (CHUA), Health Service of Castilla-La Mancha (SESCAM), Albacete, Spain.
- Raherison C INSERM U1219, Bordeaux University, Bordeaux, France.
- Sánchez-Ramos JL Department of Nursing, University of Huelva, Huelva, Spain.
- Schlünssen V Department of Public Health, Aarhus University, Aarhus, Denmark.
- Bono R Department of Public Health and Pediatrics, University of Turin, Turin, Italy.
- Corsico AG Division of Respiratory Diseases, IRCCS 'San Matteo' Hospital Foundation-University of Pavia, Pavia, Italy.
- Demoly P Département de Pneumologie et Addictologie, Hôpital Arnaud de Villeneuve, University of Montpellier, Montpellier, France.
- Dorado Arenas S Pulmonology Department, Galdakao-Usansolo Hospital, Biscay, Spain.
- Nowak D Institute and Outpatient Clinic for Occupational, Social and Environmental Medicine, Inner City Clinic, University Hospital Munich, Ludwig-Maximilians-Universität München, Munich, Germany.
- Pin I Pediatrie, CHU Grenoble Alpes, Grenoble, France.
- Weyler J Department of Epidemiology and Social Medicine and the StatUA Statistics Centre, University of Antwerp, Antwerp, Belgium.
- Jarvis D Population Health and Occupational Disease, National Heart & Lung Institute, Imperial College, London, UK.
- Svanes C Centre for International Health, Department of Global Public Health and Primary Care, University of Bergen, Bergen, Norway.
- 2018-03-14
Published in:
- International journal of epidemiology. - 2018
Adolescent
Adult
Aged
Asthma
Australia
Child
Child, Preschool
Europe
Female
Grandparents
Health Surveys
Humans
Infant
Infant, Newborn
Male
Middle Aged
Multilevel Analysis
Parents
Pregnancy
Prenatal Exposure Delayed Effects
Regression Analysis
Risk Factors
Tobacco Smoking
Young Adult
English
Background
Mothers' smoking during pregnancy increases asthma risk in their offspring. There is some evidence that grandmothers' smoking may have a similar effect, and biological plausibility that fathers' smoking during adolescence may influence offspring's health through transmittable epigenetic changes in sperm precursor cells. We evaluated the three-generation associations of tobacco smoking with asthma.
Methods
Between 2010 and 2013, at the European Community Respiratory Health Survey III clinical interview, 2233 mothers and 1964 fathers from 26 centres reported whether their offspring (aged ≤51 years) had ever had asthma and whether it had coexisted with nasal allergies or not. Mothers and fathers also provided information on their parents' (grandparents) and their own asthma, education and smoking history. Multilevel mediation models within a multicentre three-generation framework were fitted separately within the maternal (4666 offspring) and paternal (4192 offspring) lines.
Results
Fathers' smoking before they were 15 [relative risk ratio (RRR) = 1.43, 95% confidence interval (CI): 1.01-2.01] and mothers' smoking during pregnancy (RRR = 1.27, 95% CI: 1.01-1.59) were associated with asthma without nasal allergies in their offspring. Grandmothers' smoking during pregnancy was associated with asthma in their daughters [odds ratio (OR) = 1.55, 95% CI: 1.17-2.06] and with asthma with nasal allergies in their grandchildren within the maternal line (RRR = 1.25, 95% CI: 1.02-1.55).
Conclusions
Fathers' smoking during early adolescence and grandmothers' and mothers' smoking during pregnancy may independently increase asthma risk in offspring. Thus, risk factors for asthma should be sought in both parents and before conception.
Funding
European Union (Horizon 2020, GA-633212).
Mothers' smoking during pregnancy increases asthma risk in their offspring. There is some evidence that grandmothers' smoking may have a similar effect, and biological plausibility that fathers' smoking during adolescence may influence offspring's health through transmittable epigenetic changes in sperm precursor cells. We evaluated the three-generation associations of tobacco smoking with asthma.
Methods
Between 2010 and 2013, at the European Community Respiratory Health Survey III clinical interview, 2233 mothers and 1964 fathers from 26 centres reported whether their offspring (aged ≤51 years) had ever had asthma and whether it had coexisted with nasal allergies or not. Mothers and fathers also provided information on their parents' (grandparents) and their own asthma, education and smoking history. Multilevel mediation models within a multicentre three-generation framework were fitted separately within the maternal (4666 offspring) and paternal (4192 offspring) lines.
Results
Fathers' smoking before they were 15 [relative risk ratio (RRR) = 1.43, 95% confidence interval (CI): 1.01-2.01] and mothers' smoking during pregnancy (RRR = 1.27, 95% CI: 1.01-1.59) were associated with asthma without nasal allergies in their offspring. Grandmothers' smoking during pregnancy was associated with asthma in their daughters [odds ratio (OR) = 1.55, 95% CI: 1.17-2.06] and with asthma with nasal allergies in their grandchildren within the maternal line (RRR = 1.25, 95% CI: 1.02-1.55).
Conclusions
Fathers' smoking during early adolescence and grandmothers' and mothers' smoking during pregnancy may independently increase asthma risk in offspring. Thus, risk factors for asthma should be sought in both parents and before conception.
Funding
European Union (Horizon 2020, GA-633212).
- Language
-
- English
- Open access status
- hybrid
- Identifiers
-
- DOI 10.1093/ije/dyy031
- PMID 29534228
- Persistent URL
- https://sonar.ch/global/documents/92545
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