![7,12-dimethylbenz[a]anthracene-induced 'early' squamous cell carcinoma in the Golden Syrian hamster: evaluation of an animal model and comparison with 'early' forms of human squamous cell carcinoma in the upper aero-digestive tract.](/static/images/no-image.png)
Journal article
7,12-dimethylbenz[a]anthracene-induced 'early' squamous cell carcinoma in the Golden Syrian hamster: evaluation of an animal model and comparison with 'early' forms of human squamous cell carcinoma in the upper aero-digestive tract.
- Andrejevic S Department of Otolaryngology, Head and Neck Surgery--CHUV Hospital, Lausanne, Switzerland.
- Savary JF
- Fontolliet C
- Monnier P
- van Den Bergh H
- 1996-02-01
Published in:
- International journal of experimental pathology. - 1996
9,10-Dimethyl-1,2-benzanthracene
Animals
Carcinogens
Carcinoma in Situ
Carcinoma, Squamous Cell
Cheek
Cricetinae
Disease Models, Animal
Esophageal Neoplasms
Keratins
Male
Mesocricetus
Mouth Neoplasms
Neoplasm Invasiveness
Photochemotherapy
Precancerous Conditions
English
To test and optimize photodynamic therapy of early cancers in the upper aero-digestive tract and oesophagus, we sought an appropriate animal model, which was found in the 7,12-dimethylbenz[a]anthracene-induced early squamous cell carcinoma in the Golden Syrian hamster. This chemically induced neoplasm is shown, by histology and immunohistochemistry, to pass through similar stages of early cancer development as its human counterpart. Its time sequence is highly reproducible, leading to a well differentiated carcinoma in situ and microinvasive carcinoma in the hamster cheek pouch over a period of 10 weeks.
- Language
-
- English
- Open access status
- green
- Identifiers
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- DOI 10.1046/j.1365-2613.1996.956095.x
- PMID 8664146
- Persistent URL
- https://sonar.ch/global/documents/92925
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