Journal article
Potentially inappropriate medications in older adults living with HIV.
- López-Centeno B Directorate for Pharmacy and Health Products, Madrid Regional Health Service (SERMAS), Madrid, Spain.
- Badenes-Olmedo C Ontology Engineering Group (OEG), School of Telecommunications and System Engineering, Polytechnic University of Madrid (UPM), Madrid, Spain.
- Mataix-Sanjuan A Directorate for Pharmacy and Health Products, Madrid Regional Health Service (SERMAS), Madrid, Spain.
- Bellón JM Gregorio Marañón General Hospital, Institute of Health Research Gregorio Marañón (IiSGM), Madrid, Spain.
- Pérez-Latorre L Gregorio Marañón General Hospital, Institute of Health Research Gregorio Marañón (IiSGM), Madrid, Spain.
- López JC Gregorio Marañón General Hospital, Institute of Health Research Gregorio Marañón (IiSGM), Madrid, Spain.
- Benedí J Department of Pharmacology, Faculty of Pharmacy, Complutense Universtiy (UCM), Madrid, Spain.
- Khoo S Department of Pharmacology, University of Liverpool, Liverpool, UK.
- Marzolini C Division of Infectious Diseases & Hospital Epidemiology, University Hospital of Basel, Basel, Switzerland.
- Calvo-Alcántara MJ Directorate for Pharmacy and Health Products, Madrid Regional Health Service (SERMAS), Madrid, Spain.
- Berenguer J Gregorio Marañón General Hospital, Institute of Health Research Gregorio Marañón (IiSGM), Madrid, Spain.
- 2020-06-10
Published in:
- HIV medicine. - 2020
English
OBJECTIVES
We assessed the prevalence of potentially inappropriate medication (PIM) among older (≥ 65 years) people living with HIV (O-PLWH) in the region of Madrid.
METHODS
We analysed the dispensation registry of community and hospital pharmacies from the Madrid Regional Health Service (SERMAS) for the period between 1 January and 30 June 2017, looking specifically at PIMs according to the 2019 Beers criteria. Co-medications were classified according to the Anatomical Therapeutic Chemical (ATC) classification system.
RESULTS
A total of 6 636 451 individuals received medications. Of these individuals, 22 945 received antiretrovirals (ARVs), and of these 1292 were O-PLWH. Overall, 1135 (87.8%) O-PLWH were taking at least one co-medication, and polypharmacy (at least five co-medications) was observed in 852 individuals (65.9%). A PIM was identified in 482 (37.3%) O-PLWH. Factors independently associated with PIM were polypharmacy [adjusted odds ratio (aOR) 7.08; 95% confidence interval (CI) 5.16-9.72] and female sex (aOR 1.75; 95% CI 1.30-2.35). The distribution of PIMs according to ATC drug class were nervous system drugs (n = 369; 28.6%), musculoskeletal system drugs (n = 140; 10.8%), gastrointestinal and metabolism drugs (n = 72; 5.6%), cardiovascular drugs (n = 61; 4.7%), respiratory system drugs (n = 13; 1.0%), antineoplastic and immunomodulating drugs (n = 10; 0.8%), and systemic anti-infectives (n = 2; 0.2%). Five drugs accounted for 84.8% of the 482O PLWH with PIMs: lorazepam (38.2%), ibuprofen (18.0%), diazepam (10.2%), metoclopramide (9.9%), and zolpidem (8.5%).
CONCLUSIONS
Prescription of PIMs is highly prevalent in O-PLWH. Consistent with data in uninfected elderly people, the most frequently observed PIMs were benzodiazepines and nonsteroidal anti-inflammatory drugs . Targeted interventions are warranted to reduce inappropriate prescribing and polypharmacy in this vulnerable population.
We assessed the prevalence of potentially inappropriate medication (PIM) among older (≥ 65 years) people living with HIV (O-PLWH) in the region of Madrid.
METHODS
We analysed the dispensation registry of community and hospital pharmacies from the Madrid Regional Health Service (SERMAS) for the period between 1 January and 30 June 2017, looking specifically at PIMs according to the 2019 Beers criteria. Co-medications were classified according to the Anatomical Therapeutic Chemical (ATC) classification system.
RESULTS
A total of 6 636 451 individuals received medications. Of these individuals, 22 945 received antiretrovirals (ARVs), and of these 1292 were O-PLWH. Overall, 1135 (87.8%) O-PLWH were taking at least one co-medication, and polypharmacy (at least five co-medications) was observed in 852 individuals (65.9%). A PIM was identified in 482 (37.3%) O-PLWH. Factors independently associated with PIM were polypharmacy [adjusted odds ratio (aOR) 7.08; 95% confidence interval (CI) 5.16-9.72] and female sex (aOR 1.75; 95% CI 1.30-2.35). The distribution of PIMs according to ATC drug class were nervous system drugs (n = 369; 28.6%), musculoskeletal system drugs (n = 140; 10.8%), gastrointestinal and metabolism drugs (n = 72; 5.6%), cardiovascular drugs (n = 61; 4.7%), respiratory system drugs (n = 13; 1.0%), antineoplastic and immunomodulating drugs (n = 10; 0.8%), and systemic anti-infectives (n = 2; 0.2%). Five drugs accounted for 84.8% of the 482O PLWH with PIMs: lorazepam (38.2%), ibuprofen (18.0%), diazepam (10.2%), metoclopramide (9.9%), and zolpidem (8.5%).
CONCLUSIONS
Prescription of PIMs is highly prevalent in O-PLWH. Consistent with data in uninfected elderly people, the most frequently observed PIMs were benzodiazepines and nonsteroidal anti-inflammatory drugs . Targeted interventions are warranted to reduce inappropriate prescribing and polypharmacy in this vulnerable population.
- Language
-
- English
- Open access status
- closed
- Identifiers
-
- DOI 10.1111/hiv.12883
- PMID 32516849
- Persistent URL
- https://sonar.ch/global/documents/94164
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