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Drug-induced epidermolysis bullosa acquisita with antibodies to type VII collagen.
Journal article

Drug-induced epidermolysis bullosa acquisita with antibodies to type VII collagen.

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  • 2002-05-11
Published in:
  • Journal of the American Academy of Dermatology. - 2002
Adenocarcinoma
Aged
Autoantibodies
Biopsy, Needle
Collagen
Enzyme-Linked Immunosorbent Assay
Epidermolysis Bullosa Acquisita
Fluorescent Antibody Technique, Direct
Follow-Up Studies
Gentamicins
Humans
Infusions, Intravenous
Pancreatic Neoplasms
Surgical Wound Infection
Vancomycin
English We describe a 73-year-old patient who had a subepidermal bullous eruption develop after a course of antibiotics, including vancomycin. The patient had deposits of IgA and IgG in the cutaneous basement membrane zone that were located on the dermal side of 1 M NaCl-treated autologous skin. By an enzyme-linked immunosorbent assay, the patient was found to have circulating IgG antibodies directed against type VII collagen, the target antigen of epidermolysis bullosa acquisita. Our observation expands the spectrum of immune-mediated subepidermal bullous skin eruptions precipitated by drugs and lends support to the idea that a subset of these cases represents an unusual variant of drug-triggered epidermolysis bullosa acquisita.
Language
  • English
Open access status
closed
Identifiers
Persistent URL
https://sonar.ch/global/documents/95602
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