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A short, efficient synthesis of 2'-deoxypseudoisocytidine based on Heck-chemistry.
Journal article

A short, efficient synthesis of 2'-deoxypseudoisocytidine based on Heck-chemistry.

  • Mayer A Department of Chemistry & Biochemistry, University of Bern, Bern, Switzerland.
  • Leumann CJ
  • 2003-11-12
Published in:
  • Nucleosides, nucleotides & nucleic acids. - 2003
Deoxycytidine
Molecular Structure
English A novel synthesis of 2'-deoxypseudoisocytidine as well as of its phosphoramidite building block for oligonucleotide synthesis is presented. The synthesis is based on Heck-coupling between N-protected pseudoisocytosine and a silyl protected furanoid glycal. With this procedure the corresponding phosphoramidite building block is obtained in 5 steps and an overall yield of 28%.
Language
  • English
Open access status
closed
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https://sonar.ch/global/documents/978
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