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Journal article

Rare expression of BSAP (PAX-5) in mature T-cell lymphomas.

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  • 2007-04-14
Published in:
  • Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc. - 2007
Aged
Biomarkers, Tumor
Cell Lineage
Female
Gene Rearrangement, gamma-Chain T-Cell Antigen Receptor
Humans
Lymphoma, T-Cell
Lymphoma, T-Cell, Peripheral
Male
Middle Aged
PAX5 Transcription Factor
Tissue Array Analysis
English Lineage determination in lymphomas is based on the assessment of lineage-specific markers, such as the B-cell-specific activator protein of the paired box family (BSAP, PAX-5) for the B-cell lineage. BSAP is thought to be expressed exclusively in B cells from the pro-B- to the mature B-cell stage and then silenced in plasma cells. BSAP has oncogenic potential and experimental evidence shows that the T-cell lineage is prone to this effect. Herein, we report on a BSAP-positive peripheral T-cell lymphoma with monoclonal T-cell receptor gamma-gene rearrangement. To assess the relative frequency of BSAP expression in mature T-cell lymphomas, we constructed and examined a tissue microarray consisting of 43 angioimmunoblastic T-cell lymphomas and peripheral T-cell lymphomas and detected no additional BSAP-positive cases. To conclude, BSAP can probably contribute to T-cell lymphomagenesis not only in vitro, but also in vivo. It is rarely expressed in peripheral T-cell lymphoma, thus its detection on lymphoid malignancies cannot be considered definitively lineage specific.
Language
  • English
Open access status
bronze
Identifiers
Persistent URL
https://sonar.ch/global/documents/97838
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