Improved survival rates of AML patients following admission to the intensive care unit.
- Fassbind P Department of Medical Oncology, University Hospital Bern, Inselspital, University of Bern , Bern , Switzerland.
- Jeker B Department of Medical Oncology, University Hospital Bern, Inselspital, University of Bern , Bern , Switzerland.
- Mueller BU Department of Biomedical Research, University Hospital Bern, Inselspital, University of Bern , Bern , Switzerland.
- Bacher U Department of Hematology, University Hospital Bern, Inselspital, University of Bern , Bern , Switzerland.
- Zimmerli S Department of Infectious Diseases, University Hospital Bern, Inselspital, University of Bern , Bern , Switzerland.
- Endrich O Department of Medicine, University Hospital Bern, Inselspital, University of Bern , Bern , Switzerland.
- Gahl B Clinical Trial Unit Bern, University Hospital Bern, Inselspital, University of Bern , Bern , Switzerland.
- Novak U Department of Medical Oncology, University Hospital Bern, Inselspital, University of Bern , Bern , Switzerland.
- Pabst T Department of Medical Oncology, University Hospital Bern, Inselspital, University of Bern , Bern , Switzerland.
- 2019-04-04
Published in:
- Leukemia & lymphoma. - 2019
AML
ICU
intensive care
intensive treatment
outcome
prognosis
survival
Adult
Aged
Critical Care
Female
Hospital Mortality
Humans
Intensive Care Units
Kaplan-Meier Estimate
Length of Stay
Leukemia, Myeloid, Acute
Male
Middle Aged
Patient Admission
Prognosis
Proportional Hazards Models
Retrospective Studies
Risk Factors
English
Induction chemotherapy in AML patients may have life-threatening side effects requiring intensive care unit (ICU) treatment. We analyzed all AML patients receiving intensive chemotherapy at a single academic center between 01/2006-12/2016. At least one ICU admission was observed in 32% (76/240) patients, and 33% of those died following ICU admission. Whereas the ICU admission proportion remained stable, mortality after ICU admission decreased from 14% (2006-2008) to 3% (2014-2016; p = .056). The number of failing organ systems inversely correlated with surviving ICU admission (p < .001). Sepsis and renal, cardiac and pulmonary failure were each associated with higher mortality. With increasing ICU duration, survival probability decreased (p < .001), but remained >50% even after 14 days of ICU treatment. Progression-free and overall survival were comparable between ICU surviving patients and patients never needing ICU support. In conclusion, outcome after ICU admission of AML patients has substantially improved in recent years.
- Language
-
- English
- Open access status
- green
- Identifiers
-
- DOI 10.1080/10428194.2019.1594213
- PMID 30943056
- Persistent URL
- https://sonar.ch/global/documents/158
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