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Hypocretin-1 (orexin A) deficiency in acute traumatic brain injury.
Journal article

Hypocretin-1 (orexin A) deficiency in acute traumatic brain injury.

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  • 2005-07-13
Published in:
  • Neurology. - 2005
Adolescent
Adult
Aged
Autonomic Nervous System
Body Temperature
Brain Injuries
Female
Humans
Hypothalamic Area, Lateral
Hypothalamic Diseases
Hypothalamus
Hypothalamus, Posterior
Intracellular Signaling Peptides and Proteins
Male
Middle Aged
Neural Pathways
Neuropeptides
Orexins
Prospective Studies
Sleep
Sleep Wake Disorders
Wakefulness
English Hypocretin-1 is involved in the regulation of the sleep-wake cycle. The authors prospectively assessed CSF hypocretin-1 levels in 44 consecutive patients with acute traumatic brain injury (TBI). Compared with controls, hypocretin-1 levels were abnormally lower in 95% of patients with moderate to severe TBI and in 97% of patients with posttraumatic brain CT changes. Hypocretin-1 deficiency after TBI may reflect hypothalamic damage and be linked with the frequent development of posttraumatic sleep-wake disorders.
Language
  • English
Open access status
closed
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https://sonar.ch/global/documents/16698
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