Journal article
Schistosoma mansoni antigen detects Schistosoma mekongi infection.
- Nickel B Swiss Tropical and Public Health Institute, Basel, Switzerland; University of Basel, Basel, Switzerland. Electronic address: beatrice.nickel@unibas.ch.
- Sayasone S National Institute of Public Health, Vientiane, Lao Democratic People's Republic.
- Vonghachack Y Swiss Tropical and Public Health Institute, Basel, Switzerland; University of Basel, Basel, Switzerland; University of Health Sciences, Faculty of Medicine, Vientiane, Lao Democratic People's Republic.
- Odermatt P Swiss Tropical and Public Health Institute, Basel, Switzerland; University of Basel, Basel, Switzerland.
- Marti H Swiss Tropical and Public Health Institute, Basel, Switzerland; University of Basel, Basel, Switzerland.
- 2014-08-14
Published in:
- Acta tropica. - 2015
ELISA
IFA
Kato-Katz
Laos
Schistosoma mansoni
Schistosoma mekongi
Serodiagnosis
Adolescent
Adult
Aged
Animals
Antigens, Helminth
Cambodia
Child
Child, Preschool
Cross Reactions
Enzyme-Linked Immunosorbent Assay
Feces
Female
Fluorescent Antibody Technique, Indirect
Humans
Laos
Male
Middle Aged
Parasite Load
Schistosoma
Schistosoma mansoni
Schistosomiasis
Sensitivity and Specificity
Young Adult
English
Northern Cambodia and Southern Laos are highly endemic for Schistosoma mekongi. However, there is currently no immunological assay available that is specific for this form of schistosomiasis. We have validated Schistosoma mansoni antigens to detect S. mekongi-directed antibodies in human sera collected from a highly S. mekongi endemic region in Laos. On two consecutive days stool samples of 234 individuals were analyzed by Kato-Katz for presence of S. mekongi eggs and the results were correlated with serology. A sensitivity of 94.5% was calculated for a combination of ELISA and indirect fluorescence assay (IFA) as compared to the detection of S. mekongi eggs in stool samples as gold standard. The results demonstrate that S. mansoni antigens can be used for the diagnosis of S. mekongi infections.
- Language
-
- English
- Open access status
- closed
- Identifiers
-
- DOI 10.1016/j.actatropica.2014.08.001
- PMID 25116398
- Persistent URL
- https://sonar.ch/global/documents/246689
Export to…
Statistics
Document views: 39
File downloads: