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Biomarker analysis of stored blood products: emphasis on pre-analytical issues.
Journal article

Biomarker analysis of stored blood products: emphasis on pre-analytical issues.

  • Delobel J Service Régional Vaudois de Transfusion Sanguine, route de la Corniche 2, CH-1066 Epalinges, Switzerland; E-Mails: julien.delobel@mavietonsang.ch (J.D.); olivier.rubin@mavietonsang.ch (O.R.); michel.prudent@mavietonsang.ch (M.P.); david.crettaz@mavietonsang.ch (D.C.); niels.lion@mavietonsang.ch (N.L.).
  • Rubin O
  • Prudent M
  • Crettaz D
  • Tissot JD
  • Lion N
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  • 2010-12-15
Published in:
  • International journal of molecular sciences. - 2010
aging and storage lesions
biomarkers
labile blood products
pre-analytics
proteomics
Biomarkers
Blood Chemical Analysis
Blood Preservation
Blood Specimen Collection
Humans
Proteomics
English Millions of blood products are transfused every year; many lives are thus directly concerned by transfusion. The three main labile blood products used in transfusion are erythrocyte concentrates, platelet concentrates and fresh frozen plasma. Each of these products has to be stored according to its particular components. However, during storage, modifications or degradation of those components may occur, and are known as storage lesions. Thus, biomarker discovery of in vivo blood aging as well as in vitro labile blood products storage lesions is of high interest for the transfusion medicine community. Pre-analytical issues are of major importance in analyzing the various blood products during storage conditions as well as according to various protocols that are currently used in blood banks for their preparations. This paper will review key elements that have to be taken into account in the context of proteomic-based biomarker discovery applied to blood banking.
Language
  • English
Open access status
gold
Identifiers
Persistent URL
https://sonar.ch/global/documents/31272
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