Journal article
Prevalence and predictors of atrial fibrillation type among individuals with recent onset of atrial fibrillation.
- Ruperti Repilado FJ Division of Internal Medicine, Department of Medicine, University Hospital Basel, Switzerland, Cardiovascular Research Institute Basel, University Hospital Basel, Switzerland.
- Doerig L Cardiovascular Research Institute Basel, University Hospital Basel, Switzerland.
- Blum S Division of Internal Medicine, Department of Medicine, University Hospital Basel, Switzerland, Cardiovascular Research Institute Basel, University Hospital Basel, Switzerland.
- Aeschbacher S Cardiovascular Research Institute Basel, University Hospital Basel, Switzerland.
- Krisai P Division of Internal Medicine, Department of Medicine, University Hospital Basel, Switzerland, Cardiovascular Research Institute Basel, University Hospital Basel, Switzerland.
- Ammann P Division of Cardiology, Kantonsspital St. Gallen, Switzerland.
- Erne P Lab Signal Transduction, Department of Biomedicine, University of Basel, Switzerland.
- Moschovitis G Division of Cardiology, Ospedale Regionale di Lugano, Ticino, Switzerland.
- di Valentino M Division of Cardiology, Ospedale San Giovanni Bellinzona, Ticino, Switzerland.
- Shah D Division of Cardiology, University Hospital Geneva, Switzerland.
- Schläpfer J Service of Cardiology, University Hospital Lausanne, Switzerland.
- Stempfel S Division of Internal Medicine, Department of Medicine, University Hospital Basel, Switzerland, Cardiovascular Research Institute Basel, University Hospital Basel, Switzerland.
- Kühne M Cardiovascular Research Institute Basel, University Hospital Basel, Switzerland, Division of Cardiology, Department of Medicine, University Hospital Basel, Switzerland.
- Sticherling C Cardiovascular Research Institute Basel, University Hospital Basel, Switzerland, Division of Cardiology, Department of Medicine, University Hospital Basel, Switzerland.
- Osswald S Cardiovascular Research Institute Basel, University Hospital Basel, Switzerland, Division of Cardiology, Department of Medicine, University Hospital Basel, Switzerland.
- Conen D Cardiovascular Research Institute Basel, University Hospital Basel, Switzerland, Division of Cardiology, Department of Medicine, University Hospital Basel, Switzerland, Population Health Research Institute, McMaster University, Hamilton, ON, Canada.
- 2018-11-01
Published in:
- Swiss medical weekly. - 2018
Aged
Atrial Fibrillation
Disease Progression
Electrocardiography
Female
Humans
Hypertension
Longitudinal Studies
Male
Middle Aged
Prevalence
Prospective Studies
Risk Factors
Surveys and Questionnaires
Switzerland
Time Factors
English
OBJECTIVE
Atrial fibrillation (AF) is considered to be a progressive disease, starting with intermittent episodes that progress over time to more sustained events. However, little is known about the prevalence of and predictors for AF type among patients with recent-onset AF. We aimed to address these issues among a selected population of patients with AF.
METHODS
The Basel atrial fibrillation cohort (BEAT-AF) study is an ongoing prospective multicentre cohort study among patients with AF. At baseline, we obtained information on the date of AF diagnosis, AF type, comorbidities, medication and lifestyle factors. For this analysis, 486 (31.4%) out of 1550 participants with recent-onset AF (defined as AF duration <24 months) were included. Predictors for AF type (non-paroxysmal vs paroxysmal) were obtained using multivariable adjusted logistic regression models.
RESULTS
Mean age was 67 (59-75) years and 136 (28%) were women. Recent-onset paroxysmal AF was observed in 301 (62%) participants, 185 (38%) had non-paroxysmal AF - persistent AF in 148 (30.4%) and permanent AF in 37 (7.6%). In multivariable models, odds ratios for having non-paroxysmal AF around AF diagnosis were 1.03 per year increasing in age (95% confidence interval [CI] 1.01-1.05, p = 0.01); 2.70 (1.5-4.68, p = 0.0004) for history of heart failure; 3.82 (1.05-13.87, p = 0.04) for a history of hyperthyroidism and 1.04 (1.02-1.05, p <0.0001) per beat increase in heart rate.
CONCLUSION
We found a substantial proportion of AF patients with the non-paroxysmal form shortly after diagnosis. Predictors for non-paroxysmal AF were increasing age, history of heart failure or hyperthyroidism, and a higher heart rate.
Atrial fibrillation (AF) is considered to be a progressive disease, starting with intermittent episodes that progress over time to more sustained events. However, little is known about the prevalence of and predictors for AF type among patients with recent-onset AF. We aimed to address these issues among a selected population of patients with AF.
METHODS
The Basel atrial fibrillation cohort (BEAT-AF) study is an ongoing prospective multicentre cohort study among patients with AF. At baseline, we obtained information on the date of AF diagnosis, AF type, comorbidities, medication and lifestyle factors. For this analysis, 486 (31.4%) out of 1550 participants with recent-onset AF (defined as AF duration <24 months) were included. Predictors for AF type (non-paroxysmal vs paroxysmal) were obtained using multivariable adjusted logistic regression models.
RESULTS
Mean age was 67 (59-75) years and 136 (28%) were women. Recent-onset paroxysmal AF was observed in 301 (62%) participants, 185 (38%) had non-paroxysmal AF - persistent AF in 148 (30.4%) and permanent AF in 37 (7.6%). In multivariable models, odds ratios for having non-paroxysmal AF around AF diagnosis were 1.03 per year increasing in age (95% confidence interval [CI] 1.01-1.05, p = 0.01); 2.70 (1.5-4.68, p = 0.0004) for history of heart failure; 3.82 (1.05-13.87, p = 0.04) for a history of hyperthyroidism and 1.04 (1.02-1.05, p <0.0001) per beat increase in heart rate.
CONCLUSION
We found a substantial proportion of AF patients with the non-paroxysmal form shortly after diagnosis. Predictors for non-paroxysmal AF were increasing age, history of heart failure or hyperthyroidism, and a higher heart rate.
- Language
-
- English
- Identifiers
-
- DOI 10.4414/smw.2018.14652
- PMID 30378644
- Persistent URL
- https://sonar.ch/global/documents/46673
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