Journal article
Regulation of neutrophils in type 2 immune responses.
- Heeb LEM Department of Immunology, University Hospital Zurich, CH-8091 Zurich, Switzerland.
- Egholm C Department of Immunology, University Hospital Zurich, CH-8091 Zurich, Switzerland.
- Impellizzieri D Department of Immunology, University Hospital Zurich, CH-8091 Zurich, Switzerland.
- Ridder F Department of Immunology, University Hospital Zurich, CH-8091 Zurich, Switzerland.
- Boyman O Department of Immunology, University Hospital Zurich, CH-8091 Zurich, Switzerland; Faculty of Medicine, University of Zurich, CH-8006 Zurich, Switzerland. Electronic address: onur.boyman@uzh.ch.
- 2018-07-18
Published in:
- Current opinion in immunology. - 2018
English
Type 2 immune responses contribute to the resistance to helminths and toxins as well as several physiological processes. Although they usually do not participate in type 2 immune responses, neutrophils have been shown in mice to enhance the anti-helminth response, but they also contribute to increased target tissue damage. Increased pathology and morbidity is also observed in type 2 immune-mediated disorders, such as allergic asthma, when neutrophils become a predominant subset of the infiltrate. How neutrophil recruitment is regulated during type 2 immune responses is now starting to become clear, with recent data showing that signaling via the prototypic type 2 cytokine interleukin-4 receptor mediates direct and indirect inhibitory actions on neutrophils in mice and humans.
- Language
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- English
- Open access status
- closed
- Identifiers
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- DOI 10.1016/j.coi.2018.06.009
- PMID 30015087
- Persistent URL
- https://sonar.ch/global/documents/47577
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