The Microenvironmental Landscape of Brain Tumors.
- Quail DF Goodman Cancer Research Centre, McGill University, Montreal, QC H3A 1A3, Canada; Department of Physiology, McGill University, Montreal, QC H3A 1A3, Canada.
- Joyce JA Ludwig Institute for Cancer Research, University of Lausanne, 1066 Lausanne, Switzerland; Department of Oncology, University of Lausanne, Chemin des Boveresses 155, 1066 Lausanne, Switzerland. Electronic address: johanna@joycelab.org.
- 2017-03-16
Published in:
- Cancer cell. - 2017
blood-brain barrier
brain metastasis
brain tumor microenvironment
glioma
immunotherapy
tumor-associated macrophage
Blood-Brain Barrier
Brain Neoplasms
Dendritic Cells
Humans
Macrophages
Microglia
Neovascularization, Physiologic
Neutrophils
T-Lymphocytes
Tumor Microenvironment
Wound Healing
English
The brain tumor microenvironment (TME) is emerging as a critical regulator of cancer progression in primary and metastatic brain malignancies. The unique properties of this organ require a specific framework for designing TME-targeted interventions. Here, we discuss a number of these distinct features, including brain-resident cell types, the blood-brain barrier, and various aspects of the immune-suppressive environment. We also highlight recent advances in therapeutically targeting the brain TME in cancer. By developing a comprehensive understanding of the complex and interconnected microenvironmental landscape of brain malignancies we will greatly expand the range of therapeutic strategies available to target these deadly diseases.
- Language
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- English
- Open access status
- bronze
- Identifiers
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- DOI 10.1016/j.ccell.2017.02.009
- PMID 28292436
- Persistent URL
- https://sonar.ch/global/documents/560
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