Detection of Helicobacter pylori in patients with head and neck cancer: Results from a prospective comparative study combining serology, polymerase chain reaction, and rapid urease test.
- Morand GB Department of Otorhinolaryngology, Head and Neck Surgery, University Hospital Zurich, Switzerland.
- Fellmann J Department of Otorhinolaryngology, Head and Neck Surgery, University Hospital Zurich, Switzerland.
- Laske RD Department of Otorhinolaryngology, Head and Neck Surgery, University Hospital Zurich, Switzerland.
- Weisert JU Department of Otorhinolaryngology, Head and Neck Surgery, University Hospital Zurich, Switzerland.
- Soltermann A Institute of Surgical Pathology, University Hospital Zurich, Switzerland.
- Zbinden R Institute of Medical Microbiology, University of Zurich, Switzerland.
- Probst R Department of Otorhinolaryngology, Head and Neck Surgery, University Hospital Zurich, Switzerland.
- Huber GF Department of Otorhinolaryngology, Head and Neck Surgery, University Hospital Zurich, Switzerland.
- 2014-12-19
Published in:
- Head & neck. - 2016
head and neck cancer
helicobacter pylori
polymerase chain reaction (PCR)
rapid urease test
serology
Adult
Aged
Carcinoma, Squamous Cell
Female
Head and Neck Neoplasms
Helicobacter Infections
Helicobacter pylori
Humans
Logistic Models
Male
Middle Aged
Prospective Studies
Real-Time Polymerase Chain Reaction
Risk Factors
Serologic Tests
Squamous Cell Carcinoma of Head and Neck
Urease
English
BACKGROUND
The purpose of this study was to evaluate prospectively the presence and impact of the gastric carcinogen Helicobacter pylori (H. pylori) in the upper aerodigestive tract. Previous studies suggested it could represent a risk factor for head and neck squamous cell carcinoma (HNSCC).
METHODS
Serology, rapid urease test, and quantitative polymerase chain reaction (qPCR) for H. pylori were performed in patients with head and neck cancer (N = 56) and cancer-free controls (N = 90). Comparison between groups was done using logistic regression analysis.
RESULTS
Rates of positive serology and rapid urease test did not differ between the 2 groups in logistic regression analysis (p = .677 and p = .633, respectively). Birth in a developing country and age above 50 years old were predictors of positive serology (p < .001 and p = .040, respectively). Using qPCR, no biopsy showed the presence of H. pylori.
CONCLUSION
This study challenges the concept that H. pylori may be a risk factor for HNSCC.
The purpose of this study was to evaluate prospectively the presence and impact of the gastric carcinogen Helicobacter pylori (H. pylori) in the upper aerodigestive tract. Previous studies suggested it could represent a risk factor for head and neck squamous cell carcinoma (HNSCC).
METHODS
Serology, rapid urease test, and quantitative polymerase chain reaction (qPCR) for H. pylori were performed in patients with head and neck cancer (N = 56) and cancer-free controls (N = 90). Comparison between groups was done using logistic regression analysis.
RESULTS
Rates of positive serology and rapid urease test did not differ between the 2 groups in logistic regression analysis (p = .677 and p = .633, respectively). Birth in a developing country and age above 50 years old were predictors of positive serology (p < .001 and p = .040, respectively). Using qPCR, no biopsy showed the presence of H. pylori.
CONCLUSION
This study challenges the concept that H. pylori may be a risk factor for HNSCC.
- Language
-
- English
- Open access status
- green
- Identifiers
-
- DOI 10.1002/hed.23958
- PMID 25522348
- Persistent URL
- https://sonar.ch/global/documents/67382
Statistics
Document views: 22
File downloads:
- Full-text: 0