Journal article

Multi-ancestry study of blood lipid levels identifies four loci interacting with physical activity.

  • Kilpeläinen TO Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, 2200, Denmark. tuomas.kilpelainen@sund.ku.dk.
  • Bentley AR Center for Research on Genomics and Global Health, National Human Genome Research Institute, National Institutes of Health, Bethesda, 20892, MD, USA.
  • Noordam R Internal Medicine, Gerontology and Geriatrics, Leiden University Medical Center, Leiden, 2300 RC, The Netherlands.
  • Sung YJ Division of Biostatistics, Washington University School of Medicine, St. Louis, 63110, MO, USA.
  • Schwander K Division of Biostatistics, Washington University School of Medicine, St. Louis, 63110, MO, USA.
  • Winkler TW Department of Genetic Epidemiology, University of Regensburg, Regensburg, 93051, Germany.
  • Jakupović H Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, 2200, Denmark.
  • Chasman DI Preventive Medicine, Brigham and Women's Hospital, Boston, 02215, MA, USA.
  • Manning A Clinical and Translational Epidemiology Unit, Massachusetts General Hospital, Boston, 02114, MA, USA.
  • Ntalla I Clinical Pharmacology, William Harvey Research Instititute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London, EC1M 6BQ, UK.
  • Aschard H Department of Epidemiology, Harvard School of Public Health, Boston, 02115, MA, USA.
  • Brown MR Human Genetics Center, Department of Epidemiology, Human Genetics, and Environmental Sciences, School of Public Health, The University of Texas Health Science Center at Houston, Houston, 77030, TX, USA.
  • de Las Fuentes L Division of Biostatistics, Washington University School of Medicine, St. Louis, 63110, MO, USA.
  • Franceschini N Epidemiology, University of North Carolina Gillings School of Global Public Health, Chapel Hill, 27514, NC, USA.
  • Guo X The Institute for Translational Genomics and Population Sciences, Division of Genomic Outcomes, Department of Pediatrics, Los Angeles Biomedical Research Institute at Harbor-UCLA Medical Center, Torrance, 90502, CA, USA.
  • Vojinovic D Department of Epidemiology, Erasmus University Medical Center, Rotterdam, 3015 CE, The Netherlands.
  • Aslibekyan S Department of Epidemiology, University of Alabama at Birmingham, Birmingham, 35294, AL, USA.
  • Feitosa MF Division of Statistical Genomics, Department of Genetics, Washington University School of Medicine, St. Louis, 63108, MO, USA.
  • Kho M Department of Epidemiology, School of Public Health, University of Michigan, Ann Arbor, 48109, MI, USA.
  • Musani SK Jackson Heart Study, Department of Medicine, University of Mississippi Medical Center, Jackson, 39213, MS, USA.
  • Richard M Institute of Molecular Medicine, McGovern Medical School, University of Texas Health Science Center at Houston, Houston, 77030, TX, USA.
  • Wang H Division of Sleep and Circadian Disorders, Brigham and Women's Hospital, Boston, 02115, MA, USA.
  • Wang Z Human Genetics Center, Department of Epidemiology, Human Genetics, and Environmental Sciences, School of Public Health, The University of Texas Health Science Center at Houston, Houston, 77030, TX, USA.
  • Bartz TM Cardiovascular Health Research Unit, Biostatistics and Medicine, University of Washington, Seattle, 98101, WA, USA.
  • Bielak LF Department of Epidemiology, School of Public Health, University of Michigan, Ann Arbor, 48109, MI, USA.
  • Campbell A Centre for Genomic & Experimental Medicine, Institute of Genetics & Molecular Medicine, University of Edinburgh, Edinburgh, EH4 2XU, UK.
  • Dorajoo R Genome Institute of Singapore, Agency for Science Technology and Research, Singapore, 138672, Singapore.
  • Fisher V Biostatistics, Boston University School of Public Health, Boston, 02118, MA, USA.
  • Hartwig FP Postgraduate Program in Epidemiology, Federal University of Pelotas, Pelotas, 96020220, RS, Brazil.
  • Horimoto ARVR Laboratory of Genetics and Molecular Cardiology, Heart Institute (InCor), University of São Paulo Medical School, São Paulo, 01246903, SP, Brazil.
  • Li C Epidemiology and Biostatistics, University of Giorgia at Athens College of Public Health, Athens, 30602, GA, USA.
  • Lohman KK Public Health Sciences, Biostatistical Sciences, Wake Forest University Health Sciences, Winston-Salem, 27157, NC, USA.
  • Marten J Medical Research Council Human Genetics Unit, Institute of Genetics and Molecular Medicine, Institute of Genetics and Molecular Medicine, University of Edinburgh, Edinburgh, EH4 2XU, UK.
  • Sim X Saw Swee Hock School of Public Health, National University Health System and National University of Singapore, Singapore, 117549, Singapore.
  • Smith AV Icelandic Heart Association, 201, Kopavogur, Iceland.
  • Tajuddin SM Health Disparities Research Section, Laboratory of Epidemiology and Population Sciences, National Institute on Aging, National Institutes of Health, Baltimore, 21224, MD, USA.
  • Alver M Estonian Genome Center, University of Tartu, Tartu, 51010, Estonia.
  • Amini M Department of Epidemiology, University of Groningen, University Medical Center Groningen, Groningen, 9700 RB, The Netherlands.
  • Boissel M CNRS UMR 8199, European Genomic Institute for Diabetes (EGID), Institut Pasteur de Lille, University of Lille, Lille, 59000, France.
  • Chai JF Saw Swee Hock School of Public Health, National University Health System and National University of Singapore, Singapore, 117549, Singapore.
  • Chen X Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Stockholm, 17177, Sweden.
  • Divers J Department of Biostatistical Sciences, Wake Forest School of Medicine, Winston-Salem, 27157, NC, USA.
  • Evangelou E Department of Epidemiology and Biostatistics, Imperial College London, London, W2 1PG, UK.
  • Gao C Molecular Genetics and Genomics Program, Wake Forest School of Medicine, Winston-Salem, 27157, NC, USA.
  • Graff M Epidemiology, University of North Carolina Gillings School of Global Public Health, Chapel Hill, 27514, NC, USA.
  • Harris SE Centre for Genomic & Experimental Medicine, Institute of Genetics & Molecular Medicine, University of Edinburgh, Edinburgh, EH4 2XU, UK.
  • He M Department of Occupational and Environmental Health and State Key Laboratory of Environmental Health for Incubating, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430014, China.
  • Hsu FC Department of Biostatistical Sciences, Wake Forest School of Medicine, Winston-Salem, 27157, NC, USA.
  • Jackson AU Department of Biostatistics and Center for Statistical Genetics, University of Michigan, Ann Arbor, 48109, MI, USA.
  • Zhao JH MRC Epidemiology Unit, University of Cambridge, Cambridge, CB2 0QQ, UK.
  • Kraja AT Division of Statistical Genomics, Department of Genetics, Washington University School of Medicine, St. Louis, 63108, MO, USA.
  • Kühnel B Research Unit of Molecular Epidemiology, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, 85764, Germany.
  • Laguzzi F Unit of Cardiovascular Epidemiology, Institute of Environmental Medicine, Karolinska Institutet, Stockholm, 17177, Sweden.
  • Lyytikäinen LP Department of Clinical Chemistry, Fimlab Laboratories, Tampere, 33014, Finland.
  • Nolte IM Department of Epidemiology, University of Groningen, University Medical Center Groningen, Groningen, 9700 RB, The Netherlands.
  • Rauramaa R Foundation for Research in Health Exercise and Nutrition, Kuopio Research Institute of Exercise Medicine, Kuopio, 70100, Finland.
  • Riaz M College of Medicine, Biological Sciences and Psychology, Health Sciences, The Infant Mortality and Morbidity Studies (TIMMS), Leicester, LE1 7RH, UK.
  • Robino A Institute for Maternal and Child Health-IRCCS "Burlo Garofolo", Trieste, 34137, Italy.
  • Rueedi R Department of Computational Biology, University of Lausanne, Lausanne, 1015, Switzerland.
  • Stringham HM Department of Biostatistics and Center for Statistical Genetics, University of Michigan, Ann Arbor, 48109, MI, USA.
  • Takeuchi F Department of Gene Diagnostics and Therapeutics, Research Institute, National Center for Global Health and Medicine, Tokyo, 1628655, Japan.
  • van der Most PJ Department of Epidemiology, University of Groningen, University Medical Center Groningen, Groningen, 9700 RB, The Netherlands.
  • Varga TV Department of Clinical Sciences, Genetic and Molecular Epidemiology Unit, Lund University Diabetes Centre, Skåne University Hospital, Malmö, 20502, Sweden.
  • Verweij N University of Groningen, University Medical Center Groningen, Department of Cardiology, Groningen, 9700 RB, The Netherlands.
  • Ware EB Survey Research Center, Institute for Social Research, University of Michigan, Ann Arbor, 48104, MI, USA.
  • Wen W Division of Epidemiology, Department of Medicine, Vanderbilt University School of Medicine, Nashville, 37203, TN, USA.
  • Li X Department of Population and Quantitative Health Sciences, Case Western Reserve University, Cleveland, 44106, OH, USA.
  • Yanek LR Division of General Internal Medicine, Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, 21287, MD, USA.
  • Amin N Department of Epidemiology, Erasmus University Medical Center, Rotterdam, 3015 CE, The Netherlands.
  • Arnett DK Dean's Office, University of Kentucky College of Public Health, Lexington, 40536, KY, USA.
  • Boerwinkle E Human Genetics Center, Department of Epidemiology, Human Genetics, and Environmental Sciences, School of Public Health, The University of Texas Health Science Center at Houston, Houston, 77030, TX, USA.
  • Brumat M Department of Medical Sciences, University of Trieste, Trieste, 34137, Italy.
  • Cade B Division of Sleep and Circadian Disorders, Brigham and Women's Hospital, Boston, 02115, MA, USA.
  • Canouil M CNRS UMR 8199, European Genomic Institute for Diabetes (EGID), Institut Pasteur de Lille, University of Lille, Lille, 59000, France.
  • Chen YI The Institute for Translational Genomics and Population Sciences, Division of Genomic Outcomes, Department of Pediatrics, Los Angeles Biomedical Research Institute at Harbor-UCLA Medical Center, Torrance, 90502, CA, USA.
  • Concas MP Institute for Maternal and Child Health-IRCCS "Burlo Garofolo", Trieste, 34137, Italy.
  • Connell J Ninewells Hospital & Medical School, University of Dundee, Dundee, DD1 9SY, Scotland, UK.
  • de Mutsert R Clinical Epidemiology, Leiden University Medical Center, Leiden, 2300 RC, Netherlands.
  • de Silva HJ Department of Medicine, Faculty of Medicine, University of Kelaniya, Ragama, 11600, Sri Lanka.
  • de Vries PS Human Genetics Center, Department of Epidemiology, Human Genetics, and Environmental Sciences, School of Public Health, The University of Texas Health Science Center at Houston, Houston, 77030, TX, USA.
  • Demirkan A Department of Epidemiology, Erasmus University Medical Center, Rotterdam, 3015 CE, The Netherlands.
  • Ding J Department of Internal Medicine, Section on Gerontology and Geriatric Medicine, Wake Forest School of Medicine, Winston-Salem, 27157, NC, USA.
  • Eaton CB Department of Family Medicine and Epidemiology, Alpert Medical School of Brown University, Providence, 02860, RI, USA.
  • Faul JD Survey Research Center, Institute for Social Research, University of Michigan, Ann Arbor, 48104, MI, USA.
  • Friedlander Y Braun School of Public Health, Hebrew University-Hadassah Medical Center, Jerusalem, 91120, Israel.
  • Gabriel KP Department of Epidemiology, Human Genetics & Environmental Sciences, School of Public Health, The University of Texas Health Science Center at Austin, Austin, 78712, TX, USA.
  • Ghanbari M Department of Epidemiology, Erasmus University Medical Center, Rotterdam, 3015 CE, The Netherlands.
  • Giulianini F Preventive Medicine, Brigham and Women's Hospital, Boston, 02215, MA, USA.
  • Gu CC Division of Biostatistics, Washington University School of Medicine, St. Louis, 63110, MO, USA.
  • Gu D Department of Epidemiology, State Key Laboratory of Cardiovascular Disease, Fuwai Hospital, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, 100006, China.
  • Harris TB Laboratory of Epidemiology and Population Sciences, National Institute on Aging, National Institutes of Health, Bethesda, 20892, MD, USA.
  • He J Epidemiology, Tulane University School of Public Health and Tropical Medicine, New Orleans, 70112, LA, USA.
  • Heikkinen S Institute of Biomedicine, School of Medicine, University of Eastern Finland, Kuopio Campus, 70211, Finland.
  • Heng CK Department of Paediatrics, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, 119228, Singapore.
  • Hunt SC Division of Epidemiology, Department of Internal Medicine, University of Utah, Salt Lake City, 84132, UT, USA.
  • Ikram MA Department of Epidemiology, Erasmus University Medical Center, Rotterdam, 3015 CE, The Netherlands.
  • Jonas JB Department of Ophthalmology, Medical Faculty Mannheim, University Heidelberg, Mannheim, 68167, Germany.
  • Koh WP Saw Swee Hock School of Public Health, National University Health System and National University of Singapore, Singapore, 117549, Singapore.
  • Komulainen P Foundation for Research in Health Exercise and Nutrition, Kuopio Research Institute of Exercise Medicine, Kuopio, 70100, Finland.
  • Krieger JE Laboratory of Genetics and Molecular Cardiology, Heart Institute (InCor), University of São Paulo Medical School, São Paulo, 01246903, SP, Brazil.
  • Kritchevsky SB Department of Internal Medicine, Section on Gerontology and Geriatric Medicine, Wake Forest School of Medicine, Winston-Salem, 27157, NC, USA.
  • Kutalik Z Swiss Institute of Bioinformatics, 1015, Lausanne, Switzerland.
  • Kuusisto J Institute of Clinical Medicine, Internal Medicine, University of Eastern Finland, Kuopio, 70210, Finland.
  • Langefeld CD Department of Biostatistical Sciences, Wake Forest School of Medicine, Winston-Salem, 27157, NC, USA.
  • Langenberg C MRC Epidemiology Unit, University of Cambridge, Cambridge, CB2 0QQ, UK.
  • Launer LJ Laboratory of Epidemiology and Population Sciences, National Institute on Aging, National Institutes of Health, Bethesda, 20892, MD, USA.
  • Leander K Unit of Cardiovascular Epidemiology, Institute of Environmental Medicine, Karolinska Institutet, Stockholm, 17177, Sweden.
  • Lemaitre RN Cardiovascular Health Research Unit, Medicine, University of Washington, Seattle, 98101, WA, USA.
  • Lewis CE Division of Preventive Medicine, Department of Medicine, University of Alabama at Birmingham, School of Medicine, Birmingham, 35294, AL, USA.
  • Liang J Department of Population and Quantitative Health Sciences, Case Western Reserve University, Cleveland, 44106, OH, USA.
  • Liu J Estonian Genome Center, University of Tartu, Tartu, 51010, Estonia.
  • Mägi R Center for Public Health Genomics, University of Virginia School of Medicine, Charlottesville, 22908, VA, USA.
  • Manichaikul A Institute of Human Genetics, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, 85764, Germany.
  • Meitinger T Estonian Genome Center, University of Tartu, Tartu, 51010, Estonia.
  • Metspalu A Department of Psychiatry, Amsterdam Neuroscience and Amsterdam Public Health Research Institute, VU University Medical Center, Amsterdam, 1081 HV, The Netherlands.
  • Milaneschi Y Department of Genetics, University of North Carolina, Chapel Hill, 27514, NC, USA.
  • Mohlke KL Geriatrics, Medicine, University of Mississippi, Jackson, 39216, MS, USA.
  • Mosley TH The Institute of Medical Sciences, Aberdeen Biomedical Imaging Centre, University of Aberdeen, Aberdeen, AB25 2ZD, UK.
  • Murray AD Molecular Genetics Section, Laboratory of Neurogenetics, National Institute on Aging, Bethesda, 20892, MD, USA.
  • Nalls MA Saw Swee Hock School of Public Health, National University Health System and National University of Singapore, Singapore, 117549, Singapore.
  • Nang EK Department of Cardiovascular Sciences, University of Leicester, Leicester, LE3 9PQ, UK.
  • Nelson CP Cardiovascular Health Research Unit, Division of Cardiology, University of Washington, Seattle, 98101, WA, USA.
  • Nona S Department of Epidemiology, University of Colorado Denver, Aurora, 80045, CO, USA.
  • Norris JM Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, 2200, Denmark.
  • Nwuba CV Division of Endocrinology, Diabetes, and Nutrition, University of Maryland School of Medicine, Baltimore, 21201, MD, USA.
  • O'Connell J Department of Biochemistry, Wake Forest School of Medicine, Winston-Salem, 27157, NC, USA.
  • Palmer ND Epidemiology Branch, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, 20892, MD, USA.
  • Papanicolau GJ Department of Epidemiology and Biostatistics, Imperial College London, London, W2 1PG, UK.
  • Pazoki R Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Stockholm, 17177, Sweden.
  • Pedersen NL Institute of Epidemiology, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, 85764, Germany.
  • Peters A Department of Epidemiology, School of Public Health, University of Michigan, Ann Arbor, 48109, MI, USA.
  • Peyser PA Department of Public Health, Department of Medicine, University of Split, Split, 21000, Croatia.
  • Polasek O Centre for Genomic & Experimental Medicine, Institute of Genetics & Molecular Medicine, University of Edinburgh, Edinburgh, EH4 2XU, UK.
  • Porteous DJ Department of Clinical Sciences, Genetic and Molecular Epidemiology Unit, Lund University Diabetes Centre, Skåne University Hospital, Malmö, 20502, Sweden.
  • Poveda A Department of Clinical Physiology and Nuclear Medicine, Turku University Hospital, Turku, 20521, Finland.
  • Raitakari OT Center for Public Health Genomics, University of Virginia School of Medicine, Charlottesville, 22908, VA, USA.
  • Rich SS Institute for Human Genetics, Department of Epidemiology and Biostatistics, University of California, San Francisco, 94143, CA, USA.
  • Risch N Department of Epidemiology and Medicine, University of Iowa, Iowa City, 52242, IA, USA.
  • Robinson JG Preventive Medicine, Brigham and Women's Hospital, Boston, 02215, MA, USA.
  • Rose LM Centre for Global Health Research, Usher Institute of Population Health Sciences and Informatics, University of Edinburgh, Edinburgh, EH16 4UX, UK.
  • Rudan I Division of Epidemiology & Community Health, School of Public Health, University of Minnesota, Minneapolis, 55454, MN, USA.
  • Schreiner PJ MRC Epidemiology Unit, University of Cambridge, Cambridge, CB2 0QQ, UK.
  • Scott RA Kaiser Permanente Washington, Health Research Institute, Seattle, 98101, WA, USA.
  • Sidney SS Jackson Heart Study, Department of Medicine, University of Mississippi Medical Center, Jackson, 39213, MS, USA.
  • Sims M Department of Epidemiology, School of Public Health, University of Michigan, Ann Arbor, 48109, MI, USA.
  • Smith JA Department of Epidemiology, University of Groningen, University Medical Center Groningen, Groningen, 9700 RB, The Netherlands.
  • Snieder H Department of Medicine, Harvard Medical School, Boston, 02115, MA, USA.
  • Sofer T Centre for Cognitive Ageing and Cognitive Epidemiology, The University of Edinburgh, Edinburgh, EH8 9JZ, UK.
  • Starr JM Kaiser Permanente Washington, Health Research Institute, Seattle, 98101, WA, USA.
  • Sternfeld B Institute of Genetic Epidemiology, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, 85764, Germany.
  • Strauch K Department of Genetics, Stanford University, Stanford, 94305, CA, USA.
  • Tang H The Institute for Translational Genomics and Population Sciences, Division of Genomic Outcomes, Department of Pediatrics, Los Angeles Biomedical Research Institute at Harbor-UCLA Medical Center, Torrance, 90502, CA, USA.
  • Taylor KD Department of Laboratory Medicine and Pathology, University of Minnesota, Minneapolis, 55455, MN, USA.
  • Tsai MY Public Health Solutions, National Institute for Health and Welfare, Helsinki, 00271, Finland.
  • Tuomilehto J Department of Internal Medicine, Erasmus University Medical Center, Rotterdam, 3015 CE, The Netherlands.
  • Uitterlinden AG University of Groningen, University Medical Center Groningen, Department of Cardiology, Groningen, 9700 RB, The Netherlands.
  • van der Ende MY Internal Medicine, Gerontology and Geriatrics, Leiden University Medical Center, Leiden, 2300 RC, The Netherlands.
  • van Heemst D Department of Epidemiology, Erasmus University Medical Center, Rotterdam, 3015 CE, The Netherlands.
  • Voortman T Research Unit of Molecular Epidemiology, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, 85764, Germany.
  • Waldenberger M Department of Public Health & Clinical Medicine, Umeå University, Umeå, 90185, Västerbotten, Sweden.
  • Wennberg P Jackson Heart Study, School of Public Health, Jackson State University, Jackson, 39213, MS, USA.
  • Wilson G State Key Laboratory of Oncogene and Related Genes & Department of Epidemiology, Shanghai Cancer Institute, Renji Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, 200000, China.
  • Xiang YB The Institute for Translational Genomics and Population Sciences, Division of Genomic Outcomes, Department of Pediatrics, Los Angeles Biomedical Research Institute at Harbor-UCLA Medical Center, Torrance, 90502, CA, USA.
  • Yao J Department of Occupational and Environmental Health and State Key Laboratory of Environmental Health for Incubating, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430014, China.
  • Yu C Department of Epidemiology, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, 15261, PA, USA.
  • Yuan JM Department of Epidemiology, School of Public Health, University of Michigan, Ann Arbor, 48109, MI, USA.
  • Zhao W Behavioral Epidemiology Section, Laboratory of Epidemiology and Population Sciences, National Institute on Aging, National Institutes of Health, Baltimore, 21224, MD, USA.
  • Zonderman AB Division of General Internal Medicine, Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, 21287, MD, USA.
  • Becker DM Department of Biostatistics and Center for Statistical Genetics, University of Michigan, Ann Arbor, 48109, MI, USA.
  • Boehnke M Department of Biochemistry, Wake Forest School of Medicine, Winston-Salem, 27157, NC, USA.
  • Bowden DW Unit of Cardiovascular Epidemiology, Institute of Environmental Medicine, Karolinska Institutet, Stockholm, 17177, Sweden.
  • de Faire U Centre for Cognitive Ageing and Cognitive Epidemiology, The University of Edinburgh, Edinburgh, EH8 9JZ, UK.
  • Deary IJ Department of Epidemiology and Biostatistics, Imperial College London, London, W2 1PG, UK.
  • Elliott P Estonian Genome Center, University of Tartu, Tartu, 51010, Estonia.
  • Esko T Section on Nephrology, Department of Internal Medicine, Wake Forest School of Medicine, Winston-Salem, 27157, NC, USA.
  • Freedman BI CNRS UMR 8199, European Genomic Institute for Diabetes (EGID), Institut Pasteur de Lille, University of Lille, Lille, 59000, France.
  • Froguel P Institute for Maternal and Child Health-IRCCS "Burlo Garofolo", Trieste, 34137, Italy.
  • Gasparini P Research Unit of Molecular Epidemiology, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, 85764, Germany.
  • Gieger C Department of Gene Diagnostics and Therapeutics, Research Institute, National Center for Global Health and Medicine, Tokyo, 1628655, Japan.
  • Kato N Institute of Clinical Medicine, Internal Medicine, University of Eastern Finland, Kuopio, 70210, Finland.
  • Laakso M Foundation for Research in Health Exercise and Nutrition, Kuopio Research Institute of Exercise Medicine, Kuopio, 70100, Finland.
  • Lakka TA Department of Clinical Chemistry, Fimlab Laboratories, Tampere, 33014, Finland.
  • Lehtimäki T Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Stockholm, 17177, Sweden.
  • Magnusson PKE Department of Psychiatry, University of Groningen, University Medical Center Groningen, Groningen, 9713 GZ, The Netherlands.
  • Oldehinkel AJ Department of Psychiatry, Amsterdam Neuroscience and Amsterdam Public Health Research Institute, VU University Medical Center, Amsterdam, 1081 HV, The Netherlands.
  • Penninx BWJH Department of Cardiovascular Sciences, University of Leicester, Leicester, LE3 9PQ, UK.
  • Samani NJ Division of Epidemiology, Department of Medicine, Vanderbilt University School of Medicine, Nashville, 37203, TN, USA.
  • Shu XO University of Groningen, University Medical Center Groningen, Department of Cardiology, Groningen, 9700 RB, The Netherlands.
  • van der Harst P Department of Endocrinology, University of Groningen, University Medical Center Groningen, Groningen, 9713 GZ, The Netherlands.
  • Van Vliet-Ostaptchouk JV Internal Medicine, Department of Medicine, Lausanne University Hospital, Lausanne, 1011, Switzerland.
  • Vollenweider P Public Health Sciences, Wake Forest School of Medicine, Winston-Salem, 27157, NC, USA.
  • Wagenknecht LE Beijing Institute of Ophthalmology, Beijing Tongren Eye Center, Beijing Ophthalmology and Visual Science Key Lab, Beijing Tongren Hospital, Capital Medical University, Beijing, 100730, China.
  • Wang YX MRC Epidemiology Unit, University of Cambridge, Cambridge, CB2 0QQ, UK.
  • Wareham NJ Survey Research Center, Institute for Social Research, University of Michigan, Ann Arbor, 48104, MI, USA.
  • Weir DR Department of Occupational and Environmental Health and State Key Laboratory of Environmental Health for Incubating, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430014, China.
  • Wu T Division of Epidemiology, Department of Medicine, Vanderbilt University School of Medicine, Nashville, 37203, TN, USA.
  • Zheng W Department of Population and Quantitative Health Sciences, Case Western Reserve University, Cleveland, 44106, OH, USA.
  • Zhu X Health Disparities Research Section, Laboratory of Epidemiology and Population Sciences, National Institute on Aging, National Institutes of Health, Baltimore, 21224, MD, USA.
  • Evans MK Department of Clinical Sciences, Genetic and Molecular Epidemiology Unit, Lund University Diabetes Centre, Skåne University Hospital, Malmö, 20502, Sweden.
  • Franks PW Icelandic Heart Association, 201, Kopavogur, Iceland.
  • Gudnason V Medical Research Council Human Genetics Unit, Institute of Genetics and Molecular Medicine, Institute of Genetics and Molecular Medicine, University of Edinburgh, Edinburgh, EH4 2XU, UK.
  • Hayward C Postgraduate Program in Epidemiology, Federal University of Pelotas, Pelotas, 96020220, RS, Brazil.
  • Horta BL Epidemiology, Tulane University School of Public Health and Tropical Medicine, New Orleans, 70112, LA, USA.
  • Kelly TN Public Health Sciences, Epidemiology and Prevention, Wake Forest University Health Sciences, Winston-Salem, 27157, NC, USA.
  • Liu Y Epidemiology, University of North Carolina Gillings School of Global Public Health, Chapel Hill, 27514, NC, USA.
  • North KE Laboratory of Genetics and Molecular Cardiology, Heart Institute (InCor), University of São Paulo Medical School, São Paulo, 01246903, SP, Brazil.
  • Pereira AC Preventive Medicine, Brigham and Women's Hospital, Boston, 02215, MA, USA.
  • Ridker PM Saw Swee Hock School of Public Health, National University Health System and National University of Singapore, Singapore, 117549, Singapore.
  • Tai ES Saw Swee Hock School of Public Health, National University Health System and National University of Singapore, Singapore, 117549, Singapore.
  • van Dam RM Cardiology, Medicine, University of Mississippi Medical Center, Jackson, 39216, MS, USA.
  • Fox ER Department of Epidemiology, School of Public Health, University of Michigan, Ann Arbor, 48109, MI, USA.
  • Kardia SLR Biostatistics, Boston University School of Public Health, Boston, 02118, MA, USA.
  • Liu CT Clinical Epidemiology, Leiden University Medical Center, Leiden, 2300 RC, Netherlands.
  • Mook-Kanamori DO Division of Statistical Genomics, Department of Genetics, Washington University School of Medicine, St. Louis, 63108, MO, USA.
  • Province MA Division of Sleep and Circadian Disorders, Brigham and Women's Hospital, Boston, 02115, MA, USA.
  • Redline S Department of Epidemiology, Erasmus University Medical Center, Rotterdam, 3015 CE, The Netherlands.
  • van Duijn CM The Institute for Translational Genomics and Population Sciences, Division of Genomic Outcomes, Department of Pediatrics, Los Angeles Biomedical Research Institute at Harbor-UCLA Medical Center, Torrance, 90502, CA, USA.
  • Rotter JI Fred Hutchinson Cancer Research Center, University of Washington School of Public Health, Seattle, 98109, WA, USA.
  • Kooperberg CB Biostatistics, Preventive Medicine, University of Southern California, Los Angeles, 90032, CA, USA.
  • Gauderman WJ Kaiser Permanente Washington, Health Research Institute, Seattle, 98101, WA, USA.
  • Psaty BM Department of Biostatistics, University of Washington, Seattle, 98105, WA, USA.
  • Rice K Clinical Pharmacology, William Harvey Research Instititute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London, EC1M 6BQ, UK.
  • Munroe PB Institute of Molecular Medicine, McGovern Medical School, University of Texas Health Science Center at Houston, Houston, 77030, TX, USA.
  • Fornage M Biostatistics, Boston University School of Public Health, Boston, 02118, MA, USA.
  • Cupples LA Center for Research on Genomics and Global Health, National Human Genome Research Institute, National Institutes of Health, Bethesda, 20892, MD, USA.
  • Rotimi CN Human Genetics Center, Department of Epidemiology, Human Genetics, and Environmental Sciences, School of Public Health, The University of Texas Health Science Center at Houston, Houston, 77030, TX, USA.
  • Morrison AC Division of Biostatistics, Washington University School of Medicine, St. Louis, 63110, MO, USA. rao@wustl.edu.
  • Rao DC Icahn School of Medicine at Mount Sinai, The Charles Bronfman Institute for Personalized Medicine, New York, 10029, NY, USA. ruth.loos@mssm.edu.
  • Loos RJF
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  • 2019-01-24
Published in:
  • Nature communications. - 2019
English Many genetic loci affect circulating lipid levels, but it remains unknown whether lifestyle factors, such as physical activity, modify these genetic effects. To identify lipid loci interacting with physical activity, we performed genome-wide analyses of circulating HDL cholesterol, LDL cholesterol, and triglyceride levels in up to 120,979 individuals of European, African, Asian, Hispanic, and Brazilian ancestry, with follow-up of suggestive associations in an additional 131,012 individuals. We find four loci, in/near CLASP1, LHX1, SNTA1, and CNTNAP2, that are associated with circulating lipid levels through interaction with physical activity; higher levels of physical activity enhance the HDL cholesterol-increasing effects of the CLASP1, LHX1, and SNTA1 loci and attenuate the LDL cholesterol-increasing effect of the CNTNAP2 locus. The CLASP1, LHX1, and SNTA1 regions harbor genes linked to muscle function and lipid metabolism. Our results elucidate the role of physical activity interactions in the genetic contribution to blood lipid levels.
Language
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