Multi-ancestry study of blood lipid levels identifies four loci interacting with physical activity.
Kilpeläinen TONovo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, 2200, Denmark. tuomas.kilpelainen@sund.ku.dk.
Bentley ARCenter for Research on Genomics and Global Health, National Human Genome Research Institute, National Institutes of Health, Bethesda, 20892, MD, USA.
Noordam RInternal Medicine, Gerontology and Geriatrics, Leiden University Medical Center, Leiden, 2300 RC, The Netherlands.
Sung YJDivision of Biostatistics, Washington University School of Medicine, St. Louis, 63110, MO, USA.
Schwander KDivision of Biostatistics, Washington University School of Medicine, St. Louis, 63110, MO, USA.
Winkler TWDepartment of Genetic Epidemiology, University of Regensburg, Regensburg, 93051, Germany.
Jakupović HNovo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, 2200, Denmark.
Chasman DIPreventive Medicine, Brigham and Women's Hospital, Boston, 02215, MA, USA.
Manning AClinical and Translational Epidemiology Unit, Massachusetts General Hospital, Boston, 02114, MA, USA.
Ntalla IClinical Pharmacology, William Harvey Research Instititute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London, EC1M 6BQ, UK.
Aschard HDepartment of Epidemiology, Harvard School of Public Health, Boston, 02115, MA, USA.
Brown MRHuman Genetics Center, Department of Epidemiology, Human Genetics, and Environmental Sciences, School of Public Health, The University of Texas Health Science Center at Houston, Houston, 77030, TX, USA.
de Las Fuentes LDivision of Biostatistics, Washington University School of Medicine, St. Louis, 63110, MO, USA.
Franceschini NEpidemiology, University of North Carolina Gillings School of Global Public Health, Chapel Hill, 27514, NC, USA.
Guo XThe Institute for Translational Genomics and Population Sciences, Division of Genomic Outcomes, Department of Pediatrics, Los Angeles Biomedical Research Institute at Harbor-UCLA Medical Center, Torrance, 90502, CA, USA.
Vojinovic DDepartment of Epidemiology, Erasmus University Medical Center, Rotterdam, 3015 CE, The Netherlands.
Aslibekyan SDepartment of Epidemiology, University of Alabama at Birmingham, Birmingham, 35294, AL, USA.
Feitosa MFDivision of Statistical Genomics, Department of Genetics, Washington University School of Medicine, St. Louis, 63108, MO, USA.
Kho MDepartment of Epidemiology, School of Public Health, University of Michigan, Ann Arbor, 48109, MI, USA.
Musani SKJackson Heart Study, Department of Medicine, University of Mississippi Medical Center, Jackson, 39213, MS, USA.
Richard MInstitute of Molecular Medicine, McGovern Medical School, University of Texas Health Science Center at Houston, Houston, 77030, TX, USA.
Wang HDivision of Sleep and Circadian Disorders, Brigham and Women's Hospital, Boston, 02115, MA, USA.
Wang ZHuman Genetics Center, Department of Epidemiology, Human Genetics, and Environmental Sciences, School of Public Health, The University of Texas Health Science Center at Houston, Houston, 77030, TX, USA.
Bartz TMCardiovascular Health Research Unit, Biostatistics and Medicine, University of Washington, Seattle, 98101, WA, USA.
Bielak LFDepartment of Epidemiology, School of Public Health, University of Michigan, Ann Arbor, 48109, MI, USA.
Campbell ACentre for Genomic & Experimental Medicine, Institute of Genetics & Molecular Medicine, University of Edinburgh, Edinburgh, EH4 2XU, UK.
Dorajoo RGenome Institute of Singapore, Agency for Science Technology and Research, Singapore, 138672, Singapore.
Fisher VBiostatistics, Boston University School of Public Health, Boston, 02118, MA, USA.
Hartwig FPPostgraduate Program in Epidemiology, Federal University of Pelotas, Pelotas, 96020220, RS, Brazil.
Horimoto ARVRLaboratory of Genetics and Molecular Cardiology, Heart Institute (InCor), University of São Paulo Medical School, São Paulo, 01246903, SP, Brazil.
Li CEpidemiology and Biostatistics, University of Giorgia at Athens College of Public Health, Athens, 30602, GA, USA.
Lohman KKPublic Health Sciences, Biostatistical Sciences, Wake Forest University Health Sciences, Winston-Salem, 27157, NC, USA.
Marten JMedical Research Council Human Genetics Unit, Institute of Genetics and Molecular Medicine, Institute of Genetics and Molecular Medicine, University of Edinburgh, Edinburgh, EH4 2XU, UK.
Sim XSaw Swee Hock School of Public Health, National University Health System and National University of Singapore, Singapore, 117549, Singapore.
Smith AVIcelandic Heart Association, 201, Kopavogur, Iceland.
Tajuddin SMHealth Disparities Research Section, Laboratory of Epidemiology and Population Sciences, National Institute on Aging, National Institutes of Health, Baltimore, 21224, MD, USA.
Alver MEstonian Genome Center, University of Tartu, Tartu, 51010, Estonia.
Amini MDepartment of Epidemiology, University of Groningen, University Medical Center Groningen, Groningen, 9700 RB, The Netherlands.
Boissel MCNRS UMR 8199, European Genomic Institute for Diabetes (EGID), Institut Pasteur de Lille, University of Lille, Lille, 59000, France.
Chai JFSaw Swee Hock School of Public Health, National University Health System and National University of Singapore, Singapore, 117549, Singapore.
Chen XDepartment of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Stockholm, 17177, Sweden.
Divers JDepartment of Biostatistical Sciences, Wake Forest School of Medicine, Winston-Salem, 27157, NC, USA.
Evangelou EDepartment of Epidemiology and Biostatistics, Imperial College London, London, W2 1PG, UK.
Gao CMolecular Genetics and Genomics Program, Wake Forest School of Medicine, Winston-Salem, 27157, NC, USA.
Graff MEpidemiology, University of North Carolina Gillings School of Global Public Health, Chapel Hill, 27514, NC, USA.
Harris SECentre for Genomic & Experimental Medicine, Institute of Genetics & Molecular Medicine, University of Edinburgh, Edinburgh, EH4 2XU, UK.
He MDepartment of Occupational and Environmental Health and State Key Laboratory of Environmental Health for Incubating, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430014, China.
Hsu FCDepartment of Biostatistical Sciences, Wake Forest School of Medicine, Winston-Salem, 27157, NC, USA.
Jackson AUDepartment of Biostatistics and Center for Statistical Genetics, University of Michigan, Ann Arbor, 48109, MI, USA.
Zhao JHMRC Epidemiology Unit, University of Cambridge, Cambridge, CB2 0QQ, UK.
Kraja ATDivision of Statistical Genomics, Department of Genetics, Washington University School of Medicine, St. Louis, 63108, MO, USA.
Kühnel BResearch Unit of Molecular Epidemiology, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, 85764, Germany.
Laguzzi FUnit of Cardiovascular Epidemiology, Institute of Environmental Medicine, Karolinska Institutet, Stockholm, 17177, Sweden.
Lyytikäinen LPDepartment of Clinical Chemistry, Fimlab Laboratories, Tampere, 33014, Finland.
Nolte IMDepartment of Epidemiology, University of Groningen, University Medical Center Groningen, Groningen, 9700 RB, The Netherlands.
Rauramaa RFoundation for Research in Health Exercise and Nutrition, Kuopio Research Institute of Exercise Medicine, Kuopio, 70100, Finland.
Riaz MCollege of Medicine, Biological Sciences and Psychology, Health Sciences, The Infant Mortality and Morbidity Studies (TIMMS), Leicester, LE1 7RH, UK.
Robino AInstitute for Maternal and Child Health-IRCCS "Burlo Garofolo", Trieste, 34137, Italy.
Rueedi RDepartment of Computational Biology, University of Lausanne, Lausanne, 1015, Switzerland.
Stringham HMDepartment of Biostatistics and Center for Statistical Genetics, University of Michigan, Ann Arbor, 48109, MI, USA.
Takeuchi FDepartment of Gene Diagnostics and Therapeutics, Research Institute, National Center for Global Health and Medicine, Tokyo, 1628655, Japan.
van der Most PJDepartment of Epidemiology, University of Groningen, University Medical Center Groningen, Groningen, 9700 RB, The Netherlands.
Varga TVDepartment of Clinical Sciences, Genetic and Molecular Epidemiology Unit, Lund University Diabetes Centre, Skåne University Hospital, Malmö, 20502, Sweden.
Verweij NUniversity of Groningen, University Medical Center Groningen, Department of Cardiology, Groningen, 9700 RB, The Netherlands.
Ware EBSurvey Research Center, Institute for Social Research, University of Michigan, Ann Arbor, 48104, MI, USA.
Wen WDivision of Epidemiology, Department of Medicine, Vanderbilt University School of Medicine, Nashville, 37203, TN, USA.
Li XDepartment of Population and Quantitative Health Sciences, Case Western Reserve University, Cleveland, 44106, OH, USA.
Yanek LRDivision of General Internal Medicine, Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, 21287, MD, USA.
Amin NDepartment of Epidemiology, Erasmus University Medical Center, Rotterdam, 3015 CE, The Netherlands.
Arnett DKDean's Office, University of Kentucky College of Public Health, Lexington, 40536, KY, USA.
Boerwinkle EHuman Genetics Center, Department of Epidemiology, Human Genetics, and Environmental Sciences, School of Public Health, The University of Texas Health Science Center at Houston, Houston, 77030, TX, USA.
Brumat MDepartment of Medical Sciences, University of Trieste, Trieste, 34137, Italy.
Cade BDivision of Sleep and Circadian Disorders, Brigham and Women's Hospital, Boston, 02115, MA, USA.
Canouil MCNRS UMR 8199, European Genomic Institute for Diabetes (EGID), Institut Pasteur de Lille, University of Lille, Lille, 59000, France.
Chen YIThe Institute for Translational Genomics and Population Sciences, Division of Genomic Outcomes, Department of Pediatrics, Los Angeles Biomedical Research Institute at Harbor-UCLA Medical Center, Torrance, 90502, CA, USA.
Concas MPInstitute for Maternal and Child Health-IRCCS "Burlo Garofolo", Trieste, 34137, Italy.
Connell JNinewells Hospital & Medical School, University of Dundee, Dundee, DD1 9SY, Scotland, UK.
de Mutsert RClinical Epidemiology, Leiden University Medical Center, Leiden, 2300 RC, Netherlands.
de Silva HJDepartment of Medicine, Faculty of Medicine, University of Kelaniya, Ragama, 11600, Sri Lanka.
de Vries PSHuman Genetics Center, Department of Epidemiology, Human Genetics, and Environmental Sciences, School of Public Health, The University of Texas Health Science Center at Houston, Houston, 77030, TX, USA.
Demirkan ADepartment of Epidemiology, Erasmus University Medical Center, Rotterdam, 3015 CE, The Netherlands.
Ding JDepartment of Internal Medicine, Section on Gerontology and Geriatric Medicine, Wake Forest School of Medicine, Winston-Salem, 27157, NC, USA.
Eaton CBDepartment of Family Medicine and Epidemiology, Alpert Medical School of Brown University, Providence, 02860, RI, USA.
Faul JDSurvey Research Center, Institute for Social Research, University of Michigan, Ann Arbor, 48104, MI, USA.
Friedlander YBraun School of Public Health, Hebrew University-Hadassah Medical Center, Jerusalem, 91120, Israel.
Gabriel KPDepartment of Epidemiology, Human Genetics & Environmental Sciences, School of Public Health, The University of Texas Health Science Center at Austin, Austin, 78712, TX, USA.
Ghanbari MDepartment of Epidemiology, Erasmus University Medical Center, Rotterdam, 3015 CE, The Netherlands.
Giulianini FPreventive Medicine, Brigham and Women's Hospital, Boston, 02215, MA, USA.
Gu CCDivision of Biostatistics, Washington University School of Medicine, St. Louis, 63110, MO, USA.
Gu DDepartment of Epidemiology, State Key Laboratory of Cardiovascular Disease, Fuwai Hospital, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, 100006, China.
Harris TBLaboratory of Epidemiology and Population Sciences, National Institute on Aging, National Institutes of Health, Bethesda, 20892, MD, USA.
He JEpidemiology, Tulane University School of Public Health and Tropical Medicine, New Orleans, 70112, LA, USA.
Heikkinen SInstitute of Biomedicine, School of Medicine, University of Eastern Finland, Kuopio Campus, 70211, Finland.
Heng CKDepartment of Paediatrics, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, 119228, Singapore.
Hunt SCDivision of Epidemiology, Department of Internal Medicine, University of Utah, Salt Lake City, 84132, UT, USA.
Ikram MADepartment of Epidemiology, Erasmus University Medical Center, Rotterdam, 3015 CE, The Netherlands.
Jonas JBDepartment of Ophthalmology, Medical Faculty Mannheim, University Heidelberg, Mannheim, 68167, Germany.
Koh WPSaw Swee Hock School of Public Health, National University Health System and National University of Singapore, Singapore, 117549, Singapore.
Komulainen PFoundation for Research in Health Exercise and Nutrition, Kuopio Research Institute of Exercise Medicine, Kuopio, 70100, Finland.
Krieger JELaboratory of Genetics and Molecular Cardiology, Heart Institute (InCor), University of São Paulo Medical School, São Paulo, 01246903, SP, Brazil.
Kritchevsky SBDepartment of Internal Medicine, Section on Gerontology and Geriatric Medicine, Wake Forest School of Medicine, Winston-Salem, 27157, NC, USA.
Kutalik ZSwiss Institute of Bioinformatics, 1015, Lausanne, Switzerland.
Kuusisto JInstitute of Clinical Medicine, Internal Medicine, University of Eastern Finland, Kuopio, 70210, Finland.
Langefeld CDDepartment of Biostatistical Sciences, Wake Forest School of Medicine, Winston-Salem, 27157, NC, USA.
Langenberg CMRC Epidemiology Unit, University of Cambridge, Cambridge, CB2 0QQ, UK.
Launer LJLaboratory of Epidemiology and Population Sciences, National Institute on Aging, National Institutes of Health, Bethesda, 20892, MD, USA.
Leander KUnit of Cardiovascular Epidemiology, Institute of Environmental Medicine, Karolinska Institutet, Stockholm, 17177, Sweden.
Lemaitre RNCardiovascular Health Research Unit, Medicine, University of Washington, Seattle, 98101, WA, USA.
Lewis CEDivision of Preventive Medicine, Department of Medicine, University of Alabama at Birmingham, School of Medicine, Birmingham, 35294, AL, USA.
Liang JDepartment of Population and Quantitative Health Sciences, Case Western Reserve University, Cleveland, 44106, OH, USA.
Liu JEstonian Genome Center, University of Tartu, Tartu, 51010, Estonia.
Mägi RCenter for Public Health Genomics, University of Virginia School of Medicine, Charlottesville, 22908, VA, USA.
Manichaikul AInstitute of Human Genetics, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, 85764, Germany.
Meitinger TEstonian Genome Center, University of Tartu, Tartu, 51010, Estonia.
Metspalu ADepartment of Psychiatry, Amsterdam Neuroscience and Amsterdam Public Health Research Institute, VU University Medical Center, Amsterdam, 1081 HV, The Netherlands.
Milaneschi YDepartment of Genetics, University of North Carolina, Chapel Hill, 27514, NC, USA.
Mohlke KLGeriatrics, Medicine, University of Mississippi, Jackson, 39216, MS, USA.
Mosley THThe Institute of Medical Sciences, Aberdeen Biomedical Imaging Centre, University of Aberdeen, Aberdeen, AB25 2ZD, UK.
Murray ADMolecular Genetics Section, Laboratory of Neurogenetics, National Institute on Aging, Bethesda, 20892, MD, USA.
Nalls MASaw Swee Hock School of Public Health, National University Health System and National University of Singapore, Singapore, 117549, Singapore.
Nang EKDepartment of Cardiovascular Sciences, University of Leicester, Leicester, LE3 9PQ, UK.
Nelson CPCardiovascular Health Research Unit, Division of Cardiology, University of Washington, Seattle, 98101, WA, USA.
Nona SDepartment of Epidemiology, University of Colorado Denver, Aurora, 80045, CO, USA.
Norris JMNovo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, 2200, Denmark.
Nwuba CVDivision of Endocrinology, Diabetes, and Nutrition, University of Maryland School of Medicine, Baltimore, 21201, MD, USA.
O'Connell JDepartment of Biochemistry, Wake Forest School of Medicine, Winston-Salem, 27157, NC, USA.
Palmer NDEpidemiology Branch, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, 20892, MD, USA.
Papanicolau GJDepartment of Epidemiology and Biostatistics, Imperial College London, London, W2 1PG, UK.
Pazoki RDepartment of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Stockholm, 17177, Sweden.
Pedersen NLInstitute of Epidemiology, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, 85764, Germany.
Peters ADepartment of Epidemiology, School of Public Health, University of Michigan, Ann Arbor, 48109, MI, USA.
Peyser PADepartment of Public Health, Department of Medicine, University of Split, Split, 21000, Croatia.
Polasek OCentre for Genomic & Experimental Medicine, Institute of Genetics & Molecular Medicine, University of Edinburgh, Edinburgh, EH4 2XU, UK.
Porteous DJDepartment of Clinical Sciences, Genetic and Molecular Epidemiology Unit, Lund University Diabetes Centre, Skåne University Hospital, Malmö, 20502, Sweden.
Poveda ADepartment of Clinical Physiology and Nuclear Medicine, Turku University Hospital, Turku, 20521, Finland.
Raitakari OTCenter for Public Health Genomics, University of Virginia School of Medicine, Charlottesville, 22908, VA, USA.
Rich SSInstitute for Human Genetics, Department of Epidemiology and Biostatistics, University of California, San Francisco, 94143, CA, USA.
Risch NDepartment of Epidemiology and Medicine, University of Iowa, Iowa City, 52242, IA, USA.
Robinson JGPreventive Medicine, Brigham and Women's Hospital, Boston, 02215, MA, USA.
Rose LMCentre for Global Health Research, Usher Institute of Population Health Sciences and Informatics, University of Edinburgh, Edinburgh, EH16 4UX, UK.
Rudan IDivision of Epidemiology & Community Health, School of Public Health, University of Minnesota, Minneapolis, 55454, MN, USA.
Schreiner PJMRC Epidemiology Unit, University of Cambridge, Cambridge, CB2 0QQ, UK.
Scott RAKaiser Permanente Washington, Health Research Institute, Seattle, 98101, WA, USA.
Sidney SSJackson Heart Study, Department of Medicine, University of Mississippi Medical Center, Jackson, 39213, MS, USA.
Sims MDepartment of Epidemiology, School of Public Health, University of Michigan, Ann Arbor, 48109, MI, USA.
Smith JADepartment of Epidemiology, University of Groningen, University Medical Center Groningen, Groningen, 9700 RB, The Netherlands.
Snieder HDepartment of Medicine, Harvard Medical School, Boston, 02115, MA, USA.
Sofer TCentre for Cognitive Ageing and Cognitive Epidemiology, The University of Edinburgh, Edinburgh, EH8 9JZ, UK.
Starr JMKaiser Permanente Washington, Health Research Institute, Seattle, 98101, WA, USA.
Sternfeld BInstitute of Genetic Epidemiology, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, 85764, Germany.
Strauch KDepartment of Genetics, Stanford University, Stanford, 94305, CA, USA.
Tang HThe Institute for Translational Genomics and Population Sciences, Division of Genomic Outcomes, Department of Pediatrics, Los Angeles Biomedical Research Institute at Harbor-UCLA Medical Center, Torrance, 90502, CA, USA.
Taylor KDDepartment of Laboratory Medicine and Pathology, University of Minnesota, Minneapolis, 55455, MN, USA.
Tsai MYPublic Health Solutions, National Institute for Health and Welfare, Helsinki, 00271, Finland.
Tuomilehto JDepartment of Internal Medicine, Erasmus University Medical Center, Rotterdam, 3015 CE, The Netherlands.
Uitterlinden AGUniversity of Groningen, University Medical Center Groningen, Department of Cardiology, Groningen, 9700 RB, The Netherlands.
van der Ende MYInternal Medicine, Gerontology and Geriatrics, Leiden University Medical Center, Leiden, 2300 RC, The Netherlands.
van Heemst DDepartment of Epidemiology, Erasmus University Medical Center, Rotterdam, 3015 CE, The Netherlands.
Voortman TResearch Unit of Molecular Epidemiology, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, 85764, Germany.
Waldenberger MDepartment of Public Health & Clinical Medicine, Umeå University, Umeå, 90185, Västerbotten, Sweden.
Wennberg PJackson Heart Study, School of Public Health, Jackson State University, Jackson, 39213, MS, USA.
Wilson GState Key Laboratory of Oncogene and Related Genes & Department of Epidemiology, Shanghai Cancer Institute, Renji Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, 200000, China.
Xiang YBThe Institute for Translational Genomics and Population Sciences, Division of Genomic Outcomes, Department of Pediatrics, Los Angeles Biomedical Research Institute at Harbor-UCLA Medical Center, Torrance, 90502, CA, USA.
Yao JDepartment of Occupational and Environmental Health and State Key Laboratory of Environmental Health for Incubating, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430014, China.
Yu CDepartment of Epidemiology, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, 15261, PA, USA.
Yuan JMDepartment of Epidemiology, School of Public Health, University of Michigan, Ann Arbor, 48109, MI, USA.
Zhao WBehavioral Epidemiology Section, Laboratory of Epidemiology and Population Sciences, National Institute on Aging, National Institutes of Health, Baltimore, 21224, MD, USA.
Zonderman ABDivision of General Internal Medicine, Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, 21287, MD, USA.
Becker DMDepartment of Biostatistics and Center for Statistical Genetics, University of Michigan, Ann Arbor, 48109, MI, USA.
Boehnke MDepartment of Biochemistry, Wake Forest School of Medicine, Winston-Salem, 27157, NC, USA.
Bowden DWUnit of Cardiovascular Epidemiology, Institute of Environmental Medicine, Karolinska Institutet, Stockholm, 17177, Sweden.
de Faire UCentre for Cognitive Ageing and Cognitive Epidemiology, The University of Edinburgh, Edinburgh, EH8 9JZ, UK.
Deary IJDepartment of Epidemiology and Biostatistics, Imperial College London, London, W2 1PG, UK.
Elliott PEstonian Genome Center, University of Tartu, Tartu, 51010, Estonia.
Esko TSection on Nephrology, Department of Internal Medicine, Wake Forest School of Medicine, Winston-Salem, 27157, NC, USA.
Freedman BICNRS UMR 8199, European Genomic Institute for Diabetes (EGID), Institut Pasteur de Lille, University of Lille, Lille, 59000, France.
Froguel PInstitute for Maternal and Child Health-IRCCS "Burlo Garofolo", Trieste, 34137, Italy.
Gasparini PResearch Unit of Molecular Epidemiology, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, 85764, Germany.
Gieger CDepartment of Gene Diagnostics and Therapeutics, Research Institute, National Center for Global Health and Medicine, Tokyo, 1628655, Japan.
Kato NInstitute of Clinical Medicine, Internal Medicine, University of Eastern Finland, Kuopio, 70210, Finland.
Laakso MFoundation for Research in Health Exercise and Nutrition, Kuopio Research Institute of Exercise Medicine, Kuopio, 70100, Finland.
Lakka TADepartment of Clinical Chemistry, Fimlab Laboratories, Tampere, 33014, Finland.
Lehtimäki TDepartment of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Stockholm, 17177, Sweden.
Magnusson PKEDepartment of Psychiatry, University of Groningen, University Medical Center Groningen, Groningen, 9713 GZ, The Netherlands.
Oldehinkel AJDepartment of Psychiatry, Amsterdam Neuroscience and Amsterdam Public Health Research Institute, VU University Medical Center, Amsterdam, 1081 HV, The Netherlands.
Penninx BWJHDepartment of Cardiovascular Sciences, University of Leicester, Leicester, LE3 9PQ, UK.
Samani NJDivision of Epidemiology, Department of Medicine, Vanderbilt University School of Medicine, Nashville, 37203, TN, USA.
Shu XOUniversity of Groningen, University Medical Center Groningen, Department of Cardiology, Groningen, 9700 RB, The Netherlands.
van der Harst PDepartment of Endocrinology, University of Groningen, University Medical Center Groningen, Groningen, 9713 GZ, The Netherlands.
Van Vliet-Ostaptchouk JVInternal Medicine, Department of Medicine, Lausanne University Hospital, Lausanne, 1011, Switzerland.
Vollenweider PPublic Health Sciences, Wake Forest School of Medicine, Winston-Salem, 27157, NC, USA.
Wagenknecht LEBeijing Institute of Ophthalmology, Beijing Tongren Eye Center, Beijing Ophthalmology and Visual Science Key Lab, Beijing Tongren Hospital, Capital Medical University, Beijing, 100730, China.
Wang YXMRC Epidemiology Unit, University of Cambridge, Cambridge, CB2 0QQ, UK.
Wareham NJSurvey Research Center, Institute for Social Research, University of Michigan, Ann Arbor, 48104, MI, USA.
Weir DRDepartment of Occupational and Environmental Health and State Key Laboratory of Environmental Health for Incubating, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430014, China.
Wu TDivision of Epidemiology, Department of Medicine, Vanderbilt University School of Medicine, Nashville, 37203, TN, USA.
Zheng WDepartment of Population and Quantitative Health Sciences, Case Western Reserve University, Cleveland, 44106, OH, USA.
Zhu XHealth Disparities Research Section, Laboratory of Epidemiology and Population Sciences, National Institute on Aging, National Institutes of Health, Baltimore, 21224, MD, USA.
Evans MKDepartment of Clinical Sciences, Genetic and Molecular Epidemiology Unit, Lund University Diabetes Centre, Skåne University Hospital, Malmö, 20502, Sweden.
Gudnason VMedical Research Council Human Genetics Unit, Institute of Genetics and Molecular Medicine, Institute of Genetics and Molecular Medicine, University of Edinburgh, Edinburgh, EH4 2XU, UK.
Hayward CPostgraduate Program in Epidemiology, Federal University of Pelotas, Pelotas, 96020220, RS, Brazil.
Horta BLEpidemiology, Tulane University School of Public Health and Tropical Medicine, New Orleans, 70112, LA, USA.
Kelly TNPublic Health Sciences, Epidemiology and Prevention, Wake Forest University Health Sciences, Winston-Salem, 27157, NC, USA.
Liu YEpidemiology, University of North Carolina Gillings School of Global Public Health, Chapel Hill, 27514, NC, USA.
North KELaboratory of Genetics and Molecular Cardiology, Heart Institute (InCor), University of São Paulo Medical School, São Paulo, 01246903, SP, Brazil.
Pereira ACPreventive Medicine, Brigham and Women's Hospital, Boston, 02215, MA, USA.
Ridker PMSaw Swee Hock School of Public Health, National University Health System and National University of Singapore, Singapore, 117549, Singapore.
Tai ESSaw Swee Hock School of Public Health, National University Health System and National University of Singapore, Singapore, 117549, Singapore.
van Dam RMCardiology, Medicine, University of Mississippi Medical Center, Jackson, 39216, MS, USA.
Fox ERDepartment of Epidemiology, School of Public Health, University of Michigan, Ann Arbor, 48109, MI, USA.
Kardia SLRBiostatistics, Boston University School of Public Health, Boston, 02118, MA, USA.
Liu CTClinical Epidemiology, Leiden University Medical Center, Leiden, 2300 RC, Netherlands.
Mook-Kanamori DODivision of Statistical Genomics, Department of Genetics, Washington University School of Medicine, St. Louis, 63108, MO, USA.
Province MADivision of Sleep and Circadian Disorders, Brigham and Women's Hospital, Boston, 02115, MA, USA.
Redline SDepartment of Epidemiology, Erasmus University Medical Center, Rotterdam, 3015 CE, The Netherlands.
van Duijn CMThe Institute for Translational Genomics and Population Sciences, Division of Genomic Outcomes, Department of Pediatrics, Los Angeles Biomedical Research Institute at Harbor-UCLA Medical Center, Torrance, 90502, CA, USA.
Rotter JIFred Hutchinson Cancer Research Center, University of Washington School of Public Health, Seattle, 98109, WA, USA.
Kooperberg CBBiostatistics, Preventive Medicine, University of Southern California, Los Angeles, 90032, CA, USA.
Gauderman WJKaiser Permanente Washington, Health Research Institute, Seattle, 98101, WA, USA.
Psaty BMDepartment of Biostatistics, University of Washington, Seattle, 98105, WA, USA.
Rice KClinical Pharmacology, William Harvey Research Instititute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London, EC1M 6BQ, UK.
Munroe PBInstitute of Molecular Medicine, McGovern Medical School, University of Texas Health Science Center at Houston, Houston, 77030, TX, USA.
Fornage MBiostatistics, Boston University School of Public Health, Boston, 02118, MA, USA.
Cupples LACenter for Research on Genomics and Global Health, National Human Genome Research Institute, National Institutes of Health, Bethesda, 20892, MD, USA.
Rotimi CNHuman Genetics Center, Department of Epidemiology, Human Genetics, and Environmental Sciences, School of Public Health, The University of Texas Health Science Center at Houston, Houston, 77030, TX, USA.
Morrison ACDivision of Biostatistics, Washington University School of Medicine, St. Louis, 63110, MO, USA. rao@wustl.edu.
Rao DCIcahn School of Medicine at Mount Sinai, The Charles Bronfman Institute for Personalized Medicine, New York, 10029, NY, USA. ruth.loos@mssm.edu.
English
Many genetic loci affect circulating lipid levels, but it remains unknown whether lifestyle factors, such as physical activity, modify these genetic effects. To identify lipid loci interacting with physical activity, we performed genome-wide analyses of circulating HDL cholesterol, LDL cholesterol, and triglyceride levels in up to 120,979 individuals of European, African, Asian, Hispanic, and Brazilian ancestry, with follow-up of suggestive associations in an additional 131,012 individuals. We find four loci, in/near CLASP1, LHX1, SNTA1, and CNTNAP2, that are associated with circulating lipid levels through interaction with physical activity; higher levels of physical activity enhance the HDL cholesterol-increasing effects of the CLASP1, LHX1, and SNTA1 loci and attenuate the LDL cholesterol-increasing effect of the CNTNAP2 locus. The CLASP1, LHX1, and SNTA1 regions harbor genes linked to muscle function and lipid metabolism. Our results elucidate the role of physical activity interactions in the genetic contribution to blood lipid levels.